CUX2, a potential regulator of NCAM expression: Genomic characterization and analysis as a positional candidate susceptibility gene for bipolar disorder

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 105, Issue 3, 2001, Pages 295-300

  Jacobsen, Nick J O ^a   Elvidge, Gareth ^b   Franks, Emily K E ^a   O'Donovan, Michael C ^a   Craddock, Nick ^b   Owen, Michael J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Chromosome 12q; Darier disease; Hippocampus; Neurodevelopment; Neuronal plasticity

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA;

ARTICLE; CHROMOSOME 12Q; DARIER DISEASE; DNA SEQUENCE; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; GENODERMATOSIS; GENOME; HIPPOCAMPUS; HUMAN; HUMAN CELL; MANIC DEPRESSIVE PSYCHOSIS; MENTAL DISEASE; NERVE CELL PLASTICITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ADULT; AGED; BASE SEQUENCE; BIPOLAR DISORDER; CASE-CONTROL STUDIES; CHROMOSOMES, HUMAN, PAIR 12; DNA MUTATIONAL ANALYSIS; FAMILY HEALTH; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HOMEODOMAIN PROTEINS; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; NEURAL CELL ADHESION MOLECULES; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 0035826449     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.1325     Document Type: Article

References (24)

1. Genome wide microsatellite marker linkage study of bipolar affective disorders in a very large pedigree derived from a homogenous population in Quebec points to a susceptibility locus on chromosome 12
2. Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22
3. The gene for Darier's disease maps to chromosome 12q23-q24.1
4. Familial cosegregation of major affective disorder and Darier's disease (keratosis follicularis)
5. Genetics of bipolar disorder
6. Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23-24.1
7. The schedule for affective disorders and schizophrenia
8. Significant linkage between bipolar affective disorder and chromosome 12q24
9. Exclusion of the Darier's disease gene, ATP2A2, as a common susceptibility gene for bipolar disorder
10. Further evidence of familial cosegregation of major affective disorder and Darier's disease
11. Automated optimal temperature selection for denaturing high performance liquid chromatography
12. The expression of an NCAM serum fragment is positively correlated with severity of negative features in type-II schizophrenia
13. Blind analysis of denaturing high-performance liquid chromatography as a tool for mutation detection
14. Disturbances in cell recognition molecules (NCAM and L1 antigen) in the CSF of patients with schizophrenia
15. Increased neural cell adhesion molecule in the CSF of patients with mood disorder
16. Primary structure, neural-specific expression, and chromosomal localization of Cux-2, a second murine homeobox gene related to Drosophila cut
17. MatInd and MatInspector: New fast and versatile tools for detection of consensus matches in nucleotide sequence data
18. Monte Carlo tests for associations between disease and alleles at highly polymorphic loci
19. The mouse homeodomain protein Phox2 regulates NCAM promoter activity in concert with cux/CDP and is a putative determinant of neurotransmitter phenotype
20. Abnormal expression of cell recognition molecules in schizophrenia
21. VASE-containing NCAM isoforms are increased in the hippocampus in bipolar disorder but not schizophrenia
22. Alterations in hippocampal secreted NCAM in bipolar disorder and synaptophysin in schizophrenia
23. SCAN: Schedules for clinical assessment in neuropsychiatry