Questions regarding future research on aspirin and the gastrointestinal tract

American Journal of Medicine

Volumn 110, Issue 1 SUPPL. 1, 2001, Pages S74-S78

  Hirschowitz, Basil I ^a   Hawkey, Christopher J ^b  

^a University of Alabama at Birmingham   (United States)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; NONSTEROID ANTIINFLAMMATORY AGENT;

DIGESTIVE SYSTEM PERFORATION; DIGESTIVE SYSTEM ULCER; DOSE RESPONSE; DRUG EFFECT; DRUG RESEARCH; DRUG USE; GASTROINTESTINAL HEMORRHAGE; HUMAN; INTESTINE STENOSIS; PRIORITY JOURNAL; REVIEW;

EID: 0035825149     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0002-9343(00)00648-3     Document Type: Review

References (46)

1. History of aspirin and its mechanism of action
2. Safety profile of low-dose aspirin
3. Intractable upper gastrointestinal ulceration due to aspirin in patients who have undergone surgery for peptic ulcer
4. Objective evidence of aspirin use in both ulcer and non-ulcer upper and lower gastrointestinal bleeding
5. Risk of aspirin-associated major upper gastrointestinal bleeding with enteric-coated or buffered product
6. Risk of major gastrointestinal bleeding with aspirin
7. Evidence of aspirin use in both upper and lower gastrointestinal perforation
8. Nonsteroidal antiinflammatory drugs are associated with gastric outlet obstruction
9. Anorectal stenosis in patients with prolonged use of suppositories containing paracetamol and acetylsalicylic acid
10. Effects of very low dose daily, long-term aspirin therapy on gastric, duodenal, and rectal prostaglandin levels and on mucosal injury in healthy humans
11. A hearty endorsement for aspirin
12. Extent, mode and dose dependence of anticancer effects
13. Inverse association of anti-inflammatory treatment and Alzheimer's disease: Initial results of a co-twin control study
14. Non-steroidal anti-inflammatory drug use and Alzheimer's disease: A case-control study in Rochester, Minnesota, 1980 through 1984
15. Reversible prolonged skin bleeding time in acute gastrointestinal bleeding presumed due to NSAIDs
16. Aspirin related gastrointestinal bleeders have an exaggerated bleeding time response due to aspirin use
17. Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases
18. Gastric mucosal injury by fatty acid and acetyl-salicylic acids
19. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase
20. NSAID gastropathy
21. The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β
22. A new target for aspirin
23. Ingestion of aspirin prevents platelet-induced human fibroblast growth. Implications for peptic ulcer healing
24. 2 effects on stimulated normal human fibroblast cultures
25. Involvement of platelets in tumour angiogenesis?
26. Ticlopidine and clopidogrel
27. Aspirin induced apoptosis in gastric cancer cells
28. Non-steroidal anti-inflammatory drugs and variceal bleeding: A case-control study
29. Helicobacter pylori increases the risk of gastrointestinal bleeding in patients taking low dose aspirin
30. Risk stratification of upper gastrointestinal bleeding in cardiovascular patients on low dose aspirin: A cohort study
31. Aspirin: New cardiovascular uses for an old drug
32. Platelet-active drugs: The relationships among dose, effectiveness, and side effects
33. Low dose misoprostol for the prevention of low dose-aspirin induced gastroduodenal injury
34. Aspirin, paracetamol, and haematemesis and melaena
35. Use of microbleeding and an ultrathin endoscope to assess gastric mucosal protection by famotidine
36. Abolition by omeprazole of aspirin-induced gastric mucosal injury in man
37. Separation of aspirin's impairment of haemostasis from mucosal injury in the human stomach
38. Ranitidine: Differential effects on gastric bleeding and mucosal damage induced by aspirin
39. A comparison of omeprazole and misoprostol for treating and preventing ulcers associated with non-steroidal anti inflammatory drugs
40. Helicobacter pylori and nonsteroidal anti-inflammatory drugs: Interaction with proton pump inhibitor therapy for prevention of nonsteroidal anti-inflammatory drug ulcers and ulcer complications - Future research needs
41. Effect of clopidogrel on naproxen-induced gastrointestinal blood loss in healthy volunteers
42. Protection of human gastric mucosa against aspirin-enteric coating or dose reduction?
43. Thrombosis Prevention Trial. Randomised trial of low-intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at increased risk
44. Eradication of H. pylori versus maintenance acid suppression to prevent recurrent ulcer haemorrhage in high risk NSAID users: A prospective randomised study
45. Anti-thrombotic effects of a nitric oxide-releasing, gastric-sparing aspirin derivative
46. Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwitterionic phospholipids: Insight into the mechanism and reversal of NSAID-induced gastrointestinal injury