Synthesis and evaluation of efavirenz (Sustiva™) analogues as HIV-1 reverse transcriptase inhibitors: Replacement of the cyclopropylacetylene side chain

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 9, 2001, Pages 1177-1179

  Cocuzza, Anthony J ^a   Chidester, Dennis R ^a   Cordova, Beverly C ^a   Jeffrey, Susan ^a   Parsons, Rodney L ^a   Bacheler, Lee T ^a   Erickson Viitanen, Susan ^a   Trainor, George L ^a   Ko, Soo S ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLENE DERIVATIVE; BENZOXAZINONE DERIVATIVE; CYCLOPROPYLACETYLENE; EFAVIRENZ; EFAVIRENZ DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; VIRUS MUTANT;

ANTI-HIV AGENTS; HIV-1 REVERSE TRANSCRIPTASE; MUTATION; OXAZINES; REVERSE TRANSCRIPTASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0035821419     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00192-5     Document Type: Article

References (10)