Potential of lectin-N-(2-hydroxypropyl)methacrylamide copolymer-drug conjugates for the treatment of pre-cancerous conditions

Journal of Controlled Release

Volumn 74, Issue 1-3, 2001, Pages 283-293

  Wroblewski S ^a   Berenson, M ^b   Kopeckova P ^a,c   Kopecek J ^a,c  

^a University of Utah   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

Barrett's esophagus; HPMA copolymer lectin drug conjugates; Site specific delivery; Thomsen Friedenreich antigen; Ulcerative colitis

Indexed keywords

ALPHA LACTOSE; AMIDE; ANTIBODY; ANTIGEN; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; CELL SURFACE PROTEIN; FLUORESCEIN ISOTHIOCYANATE; LACTOSE; MESOCHLORIN E6; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER LEPTIN; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER PEANUT AGGLUTININ CYCLOSPORIN A; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER PEANUT AGGLUTININ MESOCHLORIN E6; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER WHEAT GERM AGGLUTININ CYCLOSPORIN A; N (2 HYDROXYPROPYL)METHACRYLAMIDE COPOLYMER WHEAT GERM AGGLUTININ MESOCHLORIN E6; PEANUT AGGLUTININ; THOMSEN FRIEDENREICH ANTIGEN; UNCLASSIFIED DRUG; WHEAT GERM AGGLUTININ;

AFFINITY CHROMATOGRAPHY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; ANTIGEN ANTIBODY COMPLEX; ANTIGEN BINDING; BARRETT ESOPHAGUS; BINDING AFFINITY; BINDING SITE; CONFERENCE PAPER; CONJUGATE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG TARGETING; GOBLET CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LECTIN BINDING; NEWBORN; NONHUMAN; PRECANCER; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; RAT; ULCERATIVE COLITIS;

ALGORITHMS; ANIMALS; ANIMALS, NEWBORN; ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; BARRETT ESOPHAGUS; COLITIS; COLONIC NEOPLASMS; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; HUMANS; LECTINS; METHACRYLATES; PEANUT AGGLUTININ; PRECANCEROUS CONDITIONS; RATS; WHEAT GERM AGGLUTININS;

EID: 0035816151     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00338-8     Document Type: Conference Paper

References (16)

1. Mucus glycoproteins and their disease in colorectal disease
2. Cytochemical localization of terminal N-acetyl-D-galactosamine residues in cellular compartments of intestinal goblet cells: Implications for the topology of O-glycosylation
3. Searching for the face of neoplasia
4. Lectin binding patterns in developing rat colon
5. The lectins: Carbohydrate-binding proteins of plants and animals
6. Lectin-binding sites in normal, hyperplastic, adenomatous and carcinomatous human colorectal cancer
7. Direct demonstration of increased expression of Thomsen-Friedenreich (TF) antigen in colonic adenocarcinoma and ulcerative colitis mucin and its concealment in normal mucin
8. Peanut lectin binding sites in human fetal colon
9. n antigens in carcinomas
10. Altered lectin binding by colonic epithelial glycoconjugates in ulcerative colitis and Crohn's disease
11. Barrett's esophagus, dysplasia and adenocarcinoma
12. Barrett's esophagus
13. Restoration of squamous mucosa after ablation of Barrett's epithelium
14. Practice Parameters Committee of the American College of Gastroenterology. Practice guidelines on the diagnosis, surveillance and therapy of Barrett's esophagus
15. Lectin-HPMA copolymer conjugates: Potential oral drug carriers for targeting diseased tissues
16. Biorecognition of HPMA copolymer-lectin conjugates as an indicator of differentiation of cell-surface glycoproteins in development, maturation, and diseases of human and rodent gastrointestinal tissues