Mutations of rubella virus vaccine TO-336 strain occurred in the attenuation process of wild progenitor virus

Vaccine

Volumn 19, Issue 20-22, 2001, Pages 2793-2802

  Kakizawa, Junko ^a,b   Nitta, Yoshihiro ^c   Yamashita, Toshiaki ^c   Ushijima, Hiroshi ^b   Katow, Shigetaka ^a  

^a NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Attenuating mutations; Rubella virus genome; Vaccine strain

Indexed keywords

AMINO ACID; HELICASE; PROTEINASE; RUBELLA VACCINE;

ANIMAL CELL; ARTICLE; ATTENUATION; CONGENITAL RUBELLA SYNDROME; CONTROLLED STUDY; GENE STRUCTURE; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; RUBELLA VIRUS; STRAIN DIFFERENCE; UNTRANSLATED REGION; VIRUS STRAIN;

BASE SEQUENCE; MOLECULAR SEQUENCE DATA; MUTATION; OPEN READING FRAMES; PHYLOGENY; PROVIRUSES; RUBELLA VACCINE; RUBELLA VIRUS; VACCINES, ATTENUATED;

EID: 0035815550     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(01)00018-4     Document Type: Article

References (18)

1. Sequence of the genome RNA of rubella virus: Evidence for genetic rearrangement during Togavirus evolution
2. Rubella, Japan, 1995-1999
3. New Japanese rubella vaccine: Comparative trials
4. Development of attenuated rubella virus vaccines in JPN
5. Identification of strain-specific nucleotide sequences in E1 and NS4 genes of rubella virus vaccine strains in JPN
6. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
7. Genomic sequence of the RA27/3 vaccine strain of rubella virus
8. Effects of defined mutations in the 5′ nontranslated region of rubella virus genomic RNA on virus viability and macromolecule synthesis
9. Rubella vaccination: Persistence of antibodies for up to 16 years
10. Sequence variation in 5′ termini of rubella virus genomes: Changes affecting structure of the 5′ proximal stem-loop
11. Mapping of genetic determinants of rubella virus associated with growth in joint tissue
12. Comparison of the complete nucleotide sequences of the genomes of the neurovirulent poliovirus P3/Leon/37 and its attenuated Sabin vaccine derivative P3/Leon 12a,b
13. Molecular analysis of rubella virus epidemiology across three continents, North America, Europe, and Asia, 1961-1997
14. Complete nucleotide sequence of the attenuated poliovirus Sabin 1 strain genome
15. Comparison of the virulent Asibi strain of yellow fever virus with the 17D vaccine strain derived from it
16. Infectious cDNA clone of the RA 27/3 vaccine strain of rubella virus
17. Genetic basis of attenuation of the Sabin type 3 oral poliovirus vaccine
18. Determinants of attenuation and temperature sensitivity in the type 1 poliovirus Sabin vaccine