A Cholera Toxin B-subunit Variant that Binds Ganglioside GM1 but Fails to Induce Toxicity

Journal of Biological Chemistry

Volumn 276, Issue 40, 2001, Pages 36939-36945

  Rodighiero, Chiara ^a,c   Fujinaga, Yukako ^a   Hirst, Timothy R ^c   Lencer, Wayne I ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CELLS; ESCHERICHIA COLI; PHYSIOLOGY; TOXICITY;

BINDING AFFINITY; MICRODOMAINS;

TOXIC MATERIALS;

ALANINE; CELL SURFACE RECEPTOR; CHOLERA TOXIN B SUBUNIT; CHOLERA TOXIN H57A; ESCHERICHIA ENTEROTOXIN; GANGLIOSIDE GM1; HISTIDINE; MEMBRANE LIPID; MUTANT PROTEIN; UNCLASSIFIED DRUG; CHOLERA TOXIN;

AMINO ACID SEQUENCE; APICAL MEMBRANE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOTOXICITY; ENDOCYTOSIS; EPITHELIUM CELL; GOLGI COMPLEX; HUMAN; HUMAN CELL; INTERNALIZATION; INTRACELLULAR TRANSPORT; MEMBRANE BINDING; MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MOTIF; PROTEIN SECRETION; PROTEIN TRANSPORT; PROTEIN VARIANT; RECEPTOR BINDING; CELL CULTURE; DRUG EFFECT; GENETICS; METABOLISM; PHYSIOLOGY;

BACTERIA (MICROORGANISMS); ESCHERICHIA; ESCHERICHIA COLI;

CHOLERA TOXIN; ENDOCYTOSIS; EPITHELIAL CELLS; G(M1) GANGLIOSIDE; HUMANS; MUTATION; TUMOR CELLS, CULTURED;

EID: 0035813092     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104245200     Document Type: Article

References (34)

1. Lencer, W. I., Hirst, T. R., and Holmes, R. K. (1999) Biochim. Biophys. Acta 1450, 177-190
2. Schmitz, A., Herrgen, H., Winkeler, A., and Herzog, V. (2000) J. Cell Biol. 148, 1203-1212
3. Tsai, B., Rodighiero, C., Lencer, W. I., and Rapoport, T. (2001) Cell 104, 937-948
4. Wolf, A. A., Jobling, M. G., Wimer-Mackin, S., Madara, J. L., Holmes, R. K., and Lencer, W. I. (1998) J. Cell Biol. 141, 917-927
5. Cuatrecasas, P. (1973) Biochemistry 12, 3558-3566
6. Holmgren, J., Lonnroth, I., Mansson, J.-E., and Svennerholm, L. (1975) Proc. Natl. Acad. Sci. U. S. A. 72, 2520-2524
7. King, C. A., and van Heyningen, W. E. (1973) J. Infect. Dis. 127, 639-647
8. Moss, J., and Vaughan, M. (1977) J. Biol. Chem. 252, 2455-2457
9. Moss, J., Stanley, S. J., and Lin, M. C. (1979) J. Biol. Chem. 254, 11993-11996
10. Cassel, D., and Selinger, Z. (1977) Proc. Natl. Acad. Sci. U. S. A. 74, 3307-3311
11. Sixma, T. K., Pronk, S. E., Kalk, H. H., Wartna, E. S., van Zanten, B. A. M., Witholt, B., and Hol, W. G. J. (1991) Nature 351, 371-377
12. Zhang, R.-G., Westbrook, M. L., Westbrook, E. M., Scott, D. L., Otwinowski, Z., Maulik, P. R., Reed, R. A., and Shipley, G. G. (1995) J. Mol. Biol. 251, 550-562
13. Zhang, R.-G., Scott, D. L., Westbrook, M. L., Nance, S., Spangler, B. D., Shipley, G. G., and Westbrook, E. M. (1995) J. Mol. Biol. 251, 563-573
14. Merritt, E. A., Sarfaty, S., van der Akker, F., L'Hoir, C., Martial, J. A., and Hol, W. G. J. (1994) Protein Sci. 3, 166-175
15. Aman, A. T., Fraser, S., Merritt, E. A., Rodigherio, C., Kenny, M. J., Ahn, M., Hol, W. G., Williams, N. A., Lencer, W. I., and Hirst, T. R. (2001) Proc. Natl. Acad. Sci. U. S. A., 98, 8536-8541
16. Lencer, W. I., Delp, C., Neutra, M. R., and Madara, J. L. (1992) J. Cell Biol. 117, 1197-1209
17. Lencer, W. I., Moe, S., Rufo, P. A., and Madara, J. L. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 10094-10098
18. Rodighiero, C., Aman, A. T., Kenny, M. J., Moss, J., Lencer, W. I., and Hirst, T. R. (1999) J. Biol. Chem. 274, 3962-3969
19. Mekalanos, J. J., Swartz, D. J., Pearson, G. D., Harford, N., Groyne, F., and de Wilde, M. (1983) Nature 306, 551-557
20. Richards, C. M., Aman, A. T., Hirst, T. R., Hill, T. J., and Williams, N. A. (2001) J. Virol. 75, 1664-1671
21. Lencer, W. I., Chu, S. H., and Walker, W. A. (1987) Infect. Immun. 55, 3126-3130
22. Bacallao, R., Garfinkel, A., Monke, S., Zampighi, G., and Mandel, L. J. (1994) J. Cell Sci. 107, 3301-3313
23. Badizadegan, K., Dickinson, B. L., Wheeler, H. E., Blumberg, R. S., Holmes, R. K., and Lencer, W. I. (2000) Am. J. Physiol. 278, G895-G904
24. Klausner, R. D., Donaldson, J. G., and Lippincott-Schwartz, J. (1992) J. Cell Biol. 116, 1071-1080
25. Pelham, H. R. B. (1991) Cell 67, 449-451
26. Lencer, W. I., de Almeida, J. B., Moe, S., Stow, J. L., Ausiello, D. A., and Madara, J. L. (1993) J. Clin. Invest. 92, 2941-2951
27. Lencer, W. I. (2001) Am. J. Physiol. 280, G781-G786
28. Bundgaard, J. R., Vuust, J., and Rehfeld, J. F. (1997) J. Biol. Chem. 272, 21700-21705
29. Huttner, W. B. (1988) Ann. Rev. Physiol. 50, 363-376
30. Williams, N. A., Stasiuk, L. M., Nashar, T. O., Richards, C. M., Lang, A. K., Day, M. J., and Hirst, T. R. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 5290-5295
31. Orlandi, P. A., and Fishman, P. H. (1998) J. Cell Biol. 141, 905-915
32. Arab, S., and Lingwood, C. A. (1996) Glycoconj. J. 13, 159-166
33. Iwabuchi, K., Handa, K., and Hakomori, S. (1998) J. Biol. Chem. 273, 33766-33773
34. Mellman, I. (1996) Annu. Rev. Cell Dev. Biol. 12, 575-625