High-performance liquid chromatographic method for the estimation of the novel investigational anti-cancer agent SR271425 and its metabolites in mouse plasma

Journal of Chromatography B: Biomedical Sciences and Applications

Volumn 759, Issue 1, 2001, Pages 175-178

  Poondru, Srinivasu ^a   Zhou, Senlin ^a   Rake, James ^b   Shackleton, Gareth ^b   Corbett, Thomas H ^a   Parchment, Ralph E ^a   Jasti, Bhaskara R ^a,c  

^a WAYNE STATE UNIVERSITY   (United States)

^b Sanofi Synthelabo Inc   (United Kingdom)

^c KARMANOS CANCER INSTITUTE   (United States)

Author keywords

SR271425

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLITES; METHANOL; PHARMACOKINETICS; PHOSPHATES; QUENCHING; TUMORS;

MOUSE PLASMA;

CHROMATOGRAPHIC ANALYSIS;

ACETONITRILE; ANTINEOPLASTIC AGENT; BUFFER; DICHLOROMETHANE; DRUG METABOLITE; METHANOL; N[1 [[2 (DIETHYLAMINO)ETHYL]AMINO] 7 METHOXY 9 OXO 9H THIOXANTHEN 4 YL]METHYLFORMAMIDE; PHOSPHATE; PLASMA PROTEIN; SR 200002; SR 200019; SR 233377; SR 271425; SR 271904; THIOXANTHENE DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG RETENTION; DRUG STRUCTURE; FLOW RATE; LIQUID LIQUID EXTRACTION; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; RADIATION DETECTION; REPRODUCIBILITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ULTRAVIOLET RADIATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MICE; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET; THIOXANTHENES;

EID: 0035812224     PISSN: 13872273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(01)00217-1     Document Type: Article

References (3)