Solubility analysis of drug compounds in supercritical carbon dioxide using static and dynamic extraction systems

Industrial and Engineering Chemistry Research

Volumn 40, Issue 7, 2001, Pages 1732-1739

  Bristow, Simon ^a   Shekunov, Boris Y ^b   York, Peter ^a,b  

^a Bradford Particle Design Plc   (United Kingdom)

^b UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; DRUG PRODUCTS; LIQUID CHROMATOGRAPHY; PHASE EQUILIBRIA; PRECIPITATION (CHEMICAL); PURIFICATION; SUPERCRITICAL FLUID EXTRACTION; THERMODYNAMICS;

SUPERCRITICAL CARBON DIOXIDE;

SOLUBILITY;

ANISAMIDE; BENZAMIDE DERIVATIVE; HYDROXYBENZOIC ACID DERIVATIVE; PARACETAMOL; UNCLASSIFIED DRUG;

EXTRACTION; LIQUID CHROMATOGRAPHY; SOLUBILITY; SPECTROSCOPY; SUPERCRITICAL CARBON DIOXIDE;

ARTICLE; DRUG ISOLATION; DRUG SOLUBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RELIABILITY; SPECTROSCOPY; THERMODYNAMICS;

EID: 0035804553     PISSN: 08885885     EISSN: None     Source Type: Journal    
DOI: 10.1021/ie0002834     Document Type: Article

References (1)

1. McHugh, M.; Krukonis, V. J. Supercritical Fluid Extraction, 2nd ed.; Butterworth-Heinemann: Boston, 1994.