Synthesis and evaluation of pteroic acid-conjugated nitroheterocyclic phosphoramidates as folate receptor-targeted alkylating agents

Journal of Medicinal Chemistry

Volumn 44, Issue 1, 2001, Pages 69-73

  Steinberg, G ^a   Borch, R F ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(5 NITRO 2 FURYL)METHYL N (PTEROYLLSYL) N,N BIS(2 BROMOETHYL)PHOSPHORODIAMIDATE; ALKYLATING AGENT; BIS(HALOETHYL)PHOSPHORAMIDATE; FOLATE RECEPTOR; FOLIC ACID; LYSINE; PHOSPHORAMIDIC ACID DERIVATIVE; PRODRUG; PTEROIC ACID; UNCLASSIFIED DRUG;

ALKYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BRASSICA; CANCER CELL CULTURE; CHEMICAL REACTION; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVITY; GENE OVEREXPRESSION; IN VITRO STUDY; NONHUMAN; TUMOR CELL;

ANTINEOPLASTIC AGENTS, ALKYLATING; CARRIER PROTEINS; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION-REDUCTION; PHOSPHORAMIDE MUSTARDS; PRODRUGS; PTERINS; RECEPTORS, CELL SURFACE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0035804302     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000306g     Document Type: Article

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