Catalysis by mutants of methylmalonyl-CoA mutase: A theoretical rationalization for a change in the rate-determining step

ChemBioChem

Volumn 2, Issue 12, 2001, Pages 919-922

  Wetmore, Stacey D ^a   Smith, David M ^a   Radom, Leo ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

Ab initio calculations; Coenzyme B12; Enzyme catalysis; Hydrogen abstraction; Methylamalonyl CoA mutase

Indexed keywords

ACYL COENZYME A; COBAMAMIDE; METHYLMALONYL COENZYME A MUTASE; METHYLMALONYL-COENZYME A; METHYLMALONYLCOENZYME A;

ARTICLE; CATALYSIS; CHEMICAL MODEL; CHEMISTRY; GENETICS; METABOLISM; MUTATION;

ACYL COENZYME A; CATALYSIS; COBAMIDES; METHYLMALONYL-COA MUTASE; MODELS, CHEMICAL; MUTATION;

EID: 0035804149     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/1439-7633(20011203)2:12<919::AID-CBIC919>3.0.CO;2-6     Document Type: Article

References (8)

1. For recent reviews, see, for example: a) B. T. Golding, W. Buckel in Comprehensive Biological Catalysis, Vol. 3 (Ed.: M. L. Sinnott), Academic Press, London, 1997, pp. 239-259;
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3. 12 (Ed.: R. Banerjee), Wiley, New York, 1999, pp. 707-730.
4. a) J. Halpern, Science 1985, 227, 869-875;
5. b) B. Beatrix, O. Zelder, F. K. Kroll, G. Orlygsson, B. T. Golding, W. Buckel, Angew. Chem. 1995, 107, 2573-2576;
6. Angew. Chem. Int. Ed. Engl. 1995, 34, 2398-2401.
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