Blockade of PAF receptors controls interleukin-8 production by regulating the activation of neutrophil CD11/CD18

European Journal of Pharmacology

Volumn 425, Issue 1, 2001, Pages 65-71

  Au, Bo ting ^a   Teixeira, Mauro M ^b   Collins, Paul D ^a   Williams, Timothy J ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

CD11 CD18 activation; Interleukin 8; Neutrophil; PAF (platelet activating factor); Phagocytosis; Zymosan

Indexed keywords

CD11 ANTIGEN; CD18 ANTIGEN; CYTOCHALASIN B; CYTOCHALASIN D; EPITOPE; INTERLEUKIN 8; MODIPAFANT; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; THROMBOCYTE ACTIVATING FACTOR RECEPTOR; ZYMOSAN;

ANTIGEN EXPRESSION; ARTICLE; CELL ACTIVATION; CELL SURFACE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG ACTIVITY; HUMAN; HUMAN CELL; NEUTROPHIL; PHAGOCYTOSIS; PRIORITY JOURNAL; RECEPTOR BLOCKING;

ANTIGENS, CD11; ANTIGENS, CD18; CELLS, CULTURED; CYTOCHALASINS; DIHYDROPYRIDINES; EPITOPES; HUMANS; IMIDAZOLES; INTERLEUKIN-8; NEUTROPHIL ACTIVATION; NEUTROPHILS; PHAGOCYTOSIS; PLATELET MEMBRANE GLYCOPROTEINS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; TIME FACTORS; ZYMOSAN;

EID: 0035800594     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01141-4     Document Type: Article

References (29)

1. UK-74505, a novel and selective PAF antagonist, exhibits potent and long lasting activity in vivo
2. Leukocyte adhesion deficiency: An inherited defect in the MAC-1, LFA-1 and p150,95 glycoproteins
3. Leucocyte adhesion molecules deficiency: Its structural basis, pathophysiology and implications for modulating the inflammatory response
4. Zymosan-induced interleukin-8 release from human neutrophils involves activation via the CD11b/CD18 receptor and endogenous platelet activating factor as an autocrine modulator
5. Effect of PDE4 inhibitors on zymosan-induced IL-8 release from human neutrophils: Synergism with prostanoids and salbutamol
6. Chemokines in inflammation and immunity
7. Phagocytosing neutrophils produce and release high amounts of the neutrophil-activating peptide 1/interleukin 8
8. Production and release of platelet-activating factor (PAF); dissociation from degranulation and superoxide production in the human neutrophil
9. Synthesis of platelet-activating factor by polymorphonuclear neutrophils stimulated with interleukin-8
10. 2+ binding epitope on leukocyte integrin α subunits
11. Interaction of leukoctye integrins with ligand is necessary but not sufficient for function
12. CD11b/CD18 integrin and a β-glucan receptor act in concert to induce the synthesis of platelet-activating factor by monocytes
13. Interaction of human monocytes, macrophages, and polymorphonuclear leukocytes with zymosan in vitro
14. Tissue injury in inflammation. Oxidants, proteinases and cationic proteins
15. Neutrophil chemoattractants generated in two phases during reperfusion of ischemic myocardium in the rabbit: Evidence for a role for C5a and interleukin-8
16. International union of pharmacology. XXII. Nomenclature for chemokine receptors
17. A comparative study of the neutrophil stimulatory activity in vitro and pro-inflammatory properties in vivo of 72 amino acid and 77 amino acid IL-8
18. Immune opsonin-independent phagocytosis by pulmonary macrophages
19. In vitro and in vivo profile of UK-74505: A novel, a highly potent and selective dihydropyridine PAF antagonist
20. Up-regulation of the iC3b receptor (CR3) is neither necessary nor sufficient to promote neutrophil aggregation
21. Membrane complement receptor type three (CR3) has lectin-like properties analogous to bovine conglutinin and functions as a receptor for zymosan and rabbit erythrocytes as well as a receptor for iC3b
22. Platelet-activating factor in anaphylaxis and phagocytosis: 1. Release from human peripheral polymorphonuclears and monocytes during the stimulation by ionophore A23187 and phagocytosis but not from degranulating basophils
23. The neutrophil in inflammation
24. Neutrophils, host defense, and inflammation: A double-edged sword
25. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
26. Effect of cytochalasin D on the mechanical properties and morphology of passive human neutrophils
27. Increased surface expression of CD11b/CD18 (Mac-1) is not required for stimulated neutrophil adherence to cultured endothelium
28. Neutrophil migration mechanisms, with an emphasis on the pulmonary vasculature
29. ARDS. Acute respiratory distress in adults