5-Formyluracil and its nucleoside derivatives confer toxicity and mutagenicity to mammalian cells by interfering with normal RNA and DNA metabolism

Toxicology Letters

Volumn 119, Issue 1, 2001, Pages 71-78

  Klungland, A ^a   Paulsen, R ^b   Rolseth, V ^b   Yamada, Y ^c   Ueno, Y ^d   Wiik, P ^b   Matsuda, A ^d   Seeberg, E ^a   Bjelland, S ^e  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b NORWEGIAN DEFENCE RESEARCH ESTABLISHMENT FFI   (Norway)

^c TAIHO PHARMACEUTICAL CO LTD   (Japan)

^d HOKKAIDO UNIVERSITY   (Japan)

^e UNIVERSITY OF STAVANGER   (Norway)

Author keywords

5 Formyl 2 deoxyuridine; 5 Formyluracil; 5 Formyluridine; Oxidative DNA damage; Oxidised nucleotide DNA precursor; Oxidised RNA nucleotide precursor

Indexed keywords

5 (HYDROXYMETHYL)URACIL; 5 FORMYLDEOXYURIDINE; 5 FORMYLURACIL; 5 FORMYLURIDINE; BASE; DNA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; NUCLEOSIDE; NUCLEOTIDE; OXYGEN RADICAL; RIBONUCLEOSIDE; THYMIDINE KINASE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANIMAL CELL; ARTICLE; BASE PAIRING; CELL GROWTH; CELL STRAIN; COLONY FORMING UNIT; CONTROLLED STUDY; CULTURE MEDIUM; CYTOTOXICITY; DNA METABOLISM; ENZYME INHIBITION; FIBROBLAST; GENE LOCUS; GENE MUTATION; HAMSTER; MAMMAL CELL; MOUSE; MUTAGENICITY; NONHUMAN; OXIDATION; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; RNA METABOLISM; RNA SYNTHESIS;

ANIMALS; CELL DIVISION; CRICETINAE; DEOXYURIDINE; DNA; FIBROBLASTS; MICE; MUTAGENS; NEURONS; RATS; RNA; TUMOR CELLS, CULTURED; URACIL; URIDINE;

CRICETINAE; CRICETULUS GRISEUS; MAMMALIA;

EID: 0035798827     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(00)00308-8     Document Type: Article

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