Novel betacellulin derivatives. Separation of the differentiation activity from the mitogenic activity

Journal of Biological Chemistry

Volumn 276, Issue 44, 2001, Pages 40698-40703

  Itoh, Takashi ^a   Kondo, Mitsuyo ^b   Tanaka, Yoko ^b   Kobayashi, Masayuki ^b   Sasada, Reiko ^b   Igarashi, Kouichi ^b   Suenaga, Masato ^b   Koyama, Nobuyuki ^b   Nishimura, Osamu ^b   Fujino, Masahiko ^b  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELLS; INSULIN; MUSCLE; PROTEINS;

MITOGENIC ACTIVITY;

BIOCHEMISTRY;

AMINO ACID; BETACELLULIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH PROMOTOR; PRIMER DNA; RECOMBINANT PROTEIN; SIGNAL PEPTIDE;

ACINAR CELL; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ACTIVITY; CELL DIFFERENTIATION; CONTROLLED STUDY; DRUG ACTIVITY; FIBROBLAST; MITOGENESIS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FOLDING; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MITOSIS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN BINDING; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; DNA PRIMERS; GROWTH SUBSTANCES; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOSIS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035798616     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106603200     Document Type: Article

References (45)

1. Shing, Y., Christofori, G., Hanahan, D., Ono, Y., Sasada, R., Igarashi, K., Folkman, J. (1993) Science 259, 1604-1607
2. Sasada, R., Ono, Y., Taniyama, Y., Shing, Y., Folkman, J., Igarashi, K. (1993) Biochem. Biophys. Res. Commun. 190, 1173-1179
3. Groenen, L. C., Nice, E. C., Burgess, A. W. (1994) Growth Factors 11, 235-257
4. Watanabe, T., Shintani, A., Nakata, M., Shing, Y., Folkman, J., Igarashi, K., Sasada, R. (1994) J. Biol. Chem. 269, 9966-9973
5. Christophe, J. (1994) Am. J. Physiol. 266, G963-G971
6. Mashima, H., Ohnishi, H., Wakabayashi, K., Mine, T., Miyagawa, J., Hanafusa, T., Seno, M., Yamada, H., Kojima, I. (1996) J. Clin. Invest. 97, 1647-1654
7. Watada, H., Kajimoto, Y., Miyagawa, J., Hanafusa, T., Hamaguchi, K., Matsuoka, T., Yamamoto, K., Matsuzawa, Y., Kawamori, R., Yamasaki, Y. (1996) Diabetes 45, 1826-1831
8. Huotari, M. A., Palgi, J., Otonkoski, T. (1998) Endocrinology 139, 1494-1499
9. Miyagawa, J., Hanafusa, O., Sasada, R., Yamamoto, K., Igarashi, K., Yamamori, K., Seno, M., Tada, H., Nammo, T., Li, M., Yamagata, K., Nakajima, H., Namba, M., Kuwajima, M., Matsuzawa, Y. (1999) Endocr. J. 46, 755-764
10. Seno, M., Tada, H., Kosaka, M., Sasada, R., Igarashi, K., Shing, Y., Folkman, J., Ueda, M., Yamada, H. (1996) Growth Factors 13, 181-191
11. Tada, H., Sasada, R., Kawaguchi, Y., Kojima, I., Gullick, W. J., Salomon, D. S., Igarashi, K., Seno, M., Yamada, H. (1999) J. Cell. Biochem. 7, 423-434
12. Yamamoto, K., Miyagawa, J., Waguri, M., Sasada, R., Igarashi, K., Li, M., Nammo, T., Moriwaki, M., Imagawa, A., Yamagata, K., Nakajima, H., Namba, M., Tochino, Y., Hanafusa, T., Matsuzawa, Y. (2000) Diabetes 49, 2021-2027
13. Dunbar, A. J., Goddard, C. (2000) Int. J. Biochem. Cell Biol. 32, 805-815
14. Yamagata, H., Nakahama, K., Suzuki, Y., Kakinuma, A., Tsukagoshi, N., Udaka, S. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 3589-3593
15. Laemmli, U. K. (1970) Nature 227, 680-689
16. Yamamoto, A., Toda, H., Sakiyama, F. (1989) J. Biochem. (Tokyo) 106, 552-554
17. Sasada, R., Kurokawa, T., Iwane, M., Igarashi, K. (1988) Mol. Cell. Biol. 8, 588-594
18. Berger, J., Hauber, J., Hauber, R., Geiger, R., Cullen, B., R. (1988) Gene 66, 1-10
19. Chan, S. J., Noyes, B. E., Agarwal, K. L., Steiner, D. F. (1979) Proc. Natl. Acad Sci. U. S. A. 76, 5036-5040
20. Winkler, M. E., O'Connor, L., Winget, M., Fendly, B. (1989) Biochemistry 28, 6373-6378
21. Dunbar, A. J., Priebe, I. K., Belford, D. A., Goddard, C. (1999) Biochem. J. 344, 713-721
22. Kallincos, N. C., Xian, C. J., Dunbar, A. J., Couper, R. T., Read, L. C. (2000) Growth Factors 18, 203-213
23. Derynck, R., Roberts, A. B., Winkler, M. E., Chen, E. Y., Goeddel, D. V. (1984) Cell 38, 287-297
24. Massague, J. (1983) J. Biol. Chem. 258, 13606-13613
25. Bell, G. I., Fong, N. M., Stempien, M. M., Wormsted, M. A., Caput, D., Ku, L. L., Urdea, M. S., Rall, L. B., Sanchez-Pescador, R. (1986) Nucleic Acids Res. 14, 8427-8446
26. Simpson, R. J., Smith, J. A., Moritz, R. L., O'Hare, M. J., Rudland, P. S., Morrison, J. R., Lloyd, C. J., Grego, B., Burgess, A. W., Nice, E. C. (1985) Eur. J. Biochem. 153, 629-637
27. Higashiyama, S., Abraham, J. A., Miller, J., Fiddes, J. C., Klagsbrun, M. (1991) Science 251, 936-939
28. Toyoda, H., Komurasaki, T., Uchida, D., Takayama, Y., Isobe, T., Okuyama, T., Hanada, K. (1995) J. Biol. Chem. 270, 7495-7500
29. Shoyab, M., Plowman, G. D., McDonald, V. L., Bradley, J. G., Todaro, G. J. (1989) Science 243, 1074-1076
30. Holmes, W. E., Sliwkowski, M. X., Akita, R. W., Henzel, W. J., Lee, J., Park, J. W., Yansura, D., Abadi, N., Raab, H., Lewis, G. D., Shepard, H. M., Kuang, W. J., Wood, W. I., Goeddel, D. V., Vandlen, R. L. (1992) Science 256, 1205-1210
31. Engler, D. A., Matsunami, R. K., Campion, S. R., Stringer, C. D., Stevens, A., Niyogi, S. K. (1988) J. Biol. Chem. 263, 12384-12390
32. Ray, P., Moy, F. J., Montelione, G. T., Liu, J. F., Narang, S. A., Scheraga, H. A., Wu, R. (1988) Biochemistry 27, 7289-7295
33. Dudgeon, T. J., Cooke, R. M., Baron, M., Campbell, I. D., Edwards, R. M., Fallon, A. (1990) FEBS Lett. 261, 392-396
34. Engler, D. A., Campion, S. R., Hauser, M. R., Cook, J. S., Niyogi, S. K. (1992) J. Biol. Chem. 267, 2274-2281
35. Matsunami, R. K., Yette, M. L., Stevens, A., Niyogi, S. K. (1991) J. Cell. Biochem. 46242-46249
36. Burgess, A. W., Lloyd, C. J., Smith, S., Stanley, E., Walker, F., Fabri, L., Simpson, R. J., Nice, E. C. (1988) Biochemistry 27, 4977-4985
37. Lazar, E., Watanabe, S., Dalton, S. Sporn, M. B. (1998) Mol. Cell. Biol. 8, 1247-1252
38. Field, J. A., Reid, R. H., Rieman, D. J., Kline, T. P., Sathe, G., Greig, R. G., Anzano, M. A. (1992) Biochem. J. 283, 91-98
39. Thompson, S. A., Harris, A., Hoang, D., Ferrer, M., Johnson, G. R. (1996) J. Biol. Chem. 271, 17927-17931
40. Nishimura, O., Suenaga, M., Ohmaeh., H. Tsuji, S., Fujino, M. (1998) J. Chem. Soc. Chem. Commun. 1135-1136
41. Riese, D. J., Bermingham, Y., Van Raaij, T. M., Buckley, S., Plowman, G. D., Stern, D. F., (1996) Oncogene 12, 345-353
42. Alimandi, M., Wang, L. M., Bottaro, D., Lee, C. C., Kuo, A., Frankel, M., Fedi, P., Tang, C., Lippman, M., Pierce, J. H. (1997) EMBO J. 16, 5608-5617
43. Pinkas-Kramarski, R., Lenferink, A. E., Bacus, S. S., Lyass, L., van de Poll, M. L., Klapper, L. N., Tzahar, E., Sela, M., van Zoelen, E. J., Yarden, Y. (1998) Oncogene 16, 1249-1258
44. Wang, L. M., Kuo, A., Alimandi, M., Veri, M. C., Lee, C. C., Kapoor, V., Ellmore, N., Chen, X. H., Pierce, J. H. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6809-6814
45. Ishiyama, N., Kanzaki, M., Seno, M., Yamada, H., Kobayashi, I., Kojima, I. (1998) Diabetologia 41, 623-628