GV196771A, an NMDA receptor/glycine site antagonist, attenuates mechanical allodynia in neuropathic rats and reduces tolerance induced by morphine in mice

European Journal of Pharmacology

Volumn 430, Issue 2-3, 2001, Pages 219-227

  Quartaroli, Mauro ^a   Fasdelli, Nicola ^a   Bettelini, Letizia ^a   Maraia, Gabriella ^a   Corsi, Mauro ^a  

^a GSK   (Italy)

Author keywords

Chronic constrictive injury; GV196771A; Mechanical allodynia; NMDA receptor glycine site antagonist; Opioid; Tolerance

Indexed keywords

4,6 DICHLORO 3 (2 OXO 1 PHENYL 3 PYRROLIDINYLIDENEMETHYL) 1H INDOLE 2 CARBOXYLIC ACID; FORMALDEHYDE; GLYCINE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; OPIATE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; MALE; MORPHINE TOLERANCE; MOUSE; NERVE LIGATION; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE;

ANIMALS; BEHAVIOR, ANIMAL; BINDING SITES; CONSTRICTION, PATHOLOGIC; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; EXCITATORY AMINO ACID ANTAGONISTS; GLYCINE; INDOLES; LIGATION; MALE; MICE; MORPHINE; NARCOTICS; NEURALGIA; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; SCIATIC NERVE; STRESS, MECHANICAL;

EID: 0035798403     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01278-X     Document Type: Article

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