Length dependence of tension generation in rat skinned cardiac muscle: Role of titin in the Frank-Starling mechanism of the heart

Circulation

Volumn 104, Issue 14, 2001, Pages 1639-1645

  Fukuda, Norio ^a   Sasaki, Daisuke ^b   Ishiwata, Shin'ichi ^b   Kurihara, Satoshi ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b WASEDA UNIVERSITY   (Japan)

Author keywords

Contractility; Myocardial contraction; Myocardium

Indexed keywords

CONNECTIN; CONTRACTILE PROTEIN; DEXTRAN; TRYPSIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART MUSCLE RELAXATION; HEART MUSCLE TENSION; HEART RIGHT VENTRICLE; MALE; MUSCLE LENGTH; MYOFILAMENT; NONHUMAN; OSMOSIS; PRIORITY JOURNAL; RAT; SARCOMERE LENGTH; SKINNED MUSCLE FIBER; STARLING LAW;

EID: 0035797846     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc3901.095898     Document Type: Article

References (33)

1. Length modulation of muscle performance: Frank-Starling law of the heart
2. The cellular basis for length-tension relation in cardiac muscle
3. Comparison between the sarcomere length-force relations of intact and skinned trabeculae from right ventricle: Influence of calcium concentrations on these relations
4. 2+ binding
5. 2+ sensitivity of tension at short sarcomere length
6. Effects of MgADP on length dependence of tension generation in skinned rat cardiac muscle
7. Myofilament lattice spacing as a function of sarcomere length in isolated rat myocardium
8. Effect of troponin I phosphorylation by protein kinase A on length-dependence of tension activation in myocardium
9. Molecular basis for the influence of muscle length on myocardial performance
10. Muscle assembly: A titanic achievement?
11. Titins: Giant proteins in charge of muscle ultrastructure and elasticity
12. Differential expression of cardiac titin isoforms and modulation of cellular stiffness
13. Towards a molecular understanding of titin
14. Understanding of sarcomere length (SL)-dependent tension generation in skinned cardiac muscle
15. Spontaneous tension oscillation in skinned bovine cardiac muscle
16. Titin develops restoring force in rat cardiac myocytes
17. Length modulation of active force in rat cardiac myocytes: Is titin the sensor?
18. Structural and functional reconstitution of thin filaments in the contractile apparatus of cardiac muscle
19. Actin removal from cardiac myocytes shows that near Z line titin attaches to actin while under tension
20. Passive tension in cardiac muscle: Contribution of collagen, titin, microtubules, and intermediate filaments
21. A physiological role for titin and nebulin in skeletal muscle
22. Interplay between passive tension and strong and weak binding cross-bridges in insect indirect flight muscle
23. Passive tension and stiffness of vertebrate skeletal and insect flight muscles: The contribution of weak cross-bridges and elastic filaments
24. X-ray diffraction evidence for the extensibility of actin and myosin filaments during muscle contraction
25. Towards a molecular understanding of the elasticity of titin
26. Temperature-induced structural changes in the myosin thick filament of skinned rabbit psoas muscle
27. X-ray diffraction studies of crossbridges weakly bound to actin in relaxed skinned fibers of rabbit psoas muscle
28. X-ray diffraction studies of the structural state of crossbridges in skinned frog sartorius muscle at low ionic strength
29. Structural and functional responses of mammalian thick filaments to alterations in myosin regulatory light chains
30. Alteration of myosin cross bridges by phosphorylation of myosin-binding protein C in cardiac muscle
31. Titin-based modulation of calcium sensitivity of active tension in mouse skinned cardiac myocytes
32. The failing human heart is unable to use the Frank-Starling mechanism
33. Titin, myosin light chains and C-protein in the developing failing human heart