New insights into the mechanistic details of the carbonic anhydrase cycle as derived from the model system [(NH3)3Zn(OH)]+/CO2: How does the H2O/HCO3- replacement step occur?

ChemBioChem

Volumn 2, Issue 3, 2001, Pages 190-198

  Mauksch, Michael ^b   Bräuer, Michael ^c   Weston, Jennie ^a   Anders, Ernst ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b INTERSHOP Communications GmbH   (Germany)

^c Trainee Pool Spring 2000   (Germany)

Author keywords

Bioinorganic chemistry; Carbonic anhydrase; Density functional calculations; Enzyme models; Lyases

Indexed keywords

BICARBONATE; CARBON DIOXIDE; CARBONATE DEHYDRATASE; DIAMINO ZINC HYDROXIDE; HISTIDINE; PROTON; SOLVENT; WATER; ZINC DERIVATIVE;

ARTICLE; BIOLOGY; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; THERMODYNAMICS;

BICARBONATES; CARBON DIOXIDE; CARBONIC ANHYDRASES; CATALYSIS; COMPUTATIONAL BIOLOGY; HISTIDINE; MODELS, MOLECULAR; PROTONS; SOLVENTS; THERMODYNAMICS; WATER; ZINC COMPOUNDS;

EID: 0035794244     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/1439-7633(20010302)2:3<190::AID-CBIC190>3.0.CO;2-7     Document Type: Article

References (5)

1. a) I. Bertini, C. Luchinat, Acc. Chem. Res. 1983, 16, 272;
2. b) J. E. Coleman in Zinc Enzymes (Eds.: I. Bertini, C. Luchinat, W. Maret, M. Zeppezauer), Birkhauser, Boston, 1986, p. 49.
3. F. Botre, G. Gros in Carbonic Anhydrase (Ed.: B. T. Storey), VCH, Weinheim, 1991.
4. J.-Y. Liang, W. N. Lipscomb, J. Am. Chem. Soc. 1986, 108, 5051.
5. P. Woolley, Nature 1975, 258, 677.