Preventive effect of ebselen on acute gastric mucosal lesion development in rats treated with compound 48/80

European Journal of Pharmacology

Volumn 414, Issue 2-3, 2001, Pages 271-279

  Kobayashi, Takashi ^a   Ohta, Yoshiji ^b   Yoshino, Junji ^a  

^a FUJITA HEALTH UNIVERSITY BANTANE HOSPITAL   (Japan)

^b FUJITA HEALTH UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Compound 48 80; Ebselen; Gastric mucosal lesion, acute rat; Glutathione peroxidase; Lipid peroxidation; Neutrophil infiltration; Xanthine oxidase

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTIOXIDANT; COMPOUND 48-80; EBSELEN; GLUTATHIONE PEROXIDASE; HISTAMINE; MYELOPEROXIDASE; ORGANOSELENIUM DERIVATIVE; SEROTONIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG SCREENING; ENZYME ACTIVITY; HISTAMINE BLOOD LEVEL; LIPID PEROXIDATION; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; RAT; SEROTONIN BLOOD LEVEL; STOMACH MUCOSA BLOOD FLOW; STOMACH MUCOSA LESION; STOMACH PROTECTION;

ANIMALS; ANTI-ULCER AGENTS; AZOLES; GASTRIC MUCOSA; GLUTATHIONE PEROXIDASE; HISTAMINE; LIPID PEROXIDATION; MALE; ORGANOSELENIUM COMPOUNDS; P-METHOXY-N-METHYLPHENETHYLAMINE; RATS; RATS, WISTAR; SEROTONIN; STOMACH ULCER; THIOBARBITURIC ACID REACTIVE SUBSTANCES; XANTHINE OXIDASE;

EID: 0035794020     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)00815-9     Document Type: Article

References (36)

1. Mucosal mast cells. Isolation and functional characteristics of rat intestinal mast cells
2. +-ATPase
3. Microsomal lipid peroxidation
4. Ultrastructure of mast cells in normal and compound 48/80-treated rats
5. Reduction of tissue histamine by compound 48/80
6. The effect of ebselen on polymorphonuclear leukocyte and lymphocyte migration to inflammatory reactions
7. The effect of ebselen on polymorphonuclear leukocyte migration to joints in rats with adjuvant arthritis
8. The effect of ebselen on T-lymphocyte migration to arthritis joints and dermal inflammatory reactions in the rats
9. New spectrophotometric assay method of xanthine oxidase in crude tissue homogenate
10. Hydrogen peroxide detoxication by glutathione peroxidase and catalase in rat liver homogenates
11. Compound 48/80 and substance P induced release of histamine and serotonin from peritoneal mast cells
12. Effect ebselen on polymorphonuclear leukocyte adhesion to and migration through cytokine-activated vascular endothelium
13. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models
14. Gastric cytoprotection by ebselen against the injury induced by necrotizing agents in rats
15. Acute antiinflammatory and gastric effect of the seleno-organic compound ebselen
16. A sensitive and specific method for the determination of histamine in human whole blood and plasma
17. A novel biologically active seleno-organic comound. I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (ebselen)
18. A novel biologically active seleno-organic compound. IV. Protective effect of PZ 51 (ebselen) against ADP-Fe induced lipid peroxidation in isolated hepatocytes
19. Action of ebselen as an antioxidant against lipid peroxidation
20. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
21. Relationship between changes of active oxygen metabolism and blood flow and formation, progression, and recovery of lesions in gastric mucosa of rats with a single treatment of compound 48/80, a mast cell degranulator
22. Participation of xanthine-xanthine oxidase system and neutrophils in development of acute gastric mucosal lesions in rats with a single treatment of compound 48/80, a mast cell degranulator
23. Role of endogenous serotonin and histamine in the pathogenesis of gastric mucosal lesions in unanesthetised rats with a single treatment of compound 48/80, a mast cell degranulator
24. Simultaneous micro-determination of serotonin and 5-hydroxyindole-3-acetic acid with 5-hydroxy-Na-methyltrptamine, as an internal standard in biological materials by high-performance liquid chromatography with electrochemical detection
25. A method for the fluorometric assay of histamine in tissue
26. Assay method of myeloperoxidase in human polymorphonuclear leukocytes
27. Antisecretory and antiulcer effects of ebselen, a seleno-organic compound, in rats
28. +-ATPase by the seleno-organic compound ebselen
29. Ebselen, a seleno-organic compound, protects against ethanol-induced murine gastric mucosal injury in both in vivo and in vitro systems
30. Pathogenesis of compound 48/80-induced gastric lesions in rats
31. Differential effect of ebselen on compound 48/80- and anti-IgE-induced histamine release from rat peritoneal mast cells
32. Effects of ebselen on acute gastric mucosal injury in rats
33. Protection by seleno-organic compound, ebselen, against acute gastric mucosal injury induced by ischemia-reperfusion in rats
34. Ebselen as protection against ethanol-induced toxicity in rat stomach
35. A novel biologically active seleno-organic compound. II. Activity of PZ 51 in relation to glutathione peroxidase
36. Role of nitric oxide in pathogenesis of gastric mucosal damage induced by compound 48/80 in rats