The crystal structure of the Fab fragment of the monoclonal antibody MAK33: Implications for folding and interaction with the chaperone BiP

Journal of Biological Chemistry

Volumn 276, Issue 5, 2001, Pages 3287-3294

  Augustine, John G ^a   De La Calle, Agustin ^a   Knarr, Gerhard ^b   Buchner, Johannes ^b   Frederick, Christin A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN-ANTIBODY REACTIONS; BIOCHEMISTRY; CHEMICAL BONDS; COMPLEXATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYMES; IMMUNOLOGY; ISOMERIZATION;

IMMUNOGLOBULINS;

MONOCLONAL ANTIBODIES;

CHAPERONE; CREATINE KINASE; CYCLOPHILIN; GLUCOSE REGULATED PROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY MAK 33; PROLINE; UNCLASSIFIED DRUG; CARRIER PROTEIN; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; PEPTIDE FRAGMENT;

ANTIBODY STRUCTURE; ARTICLE; CRYSTAL STRUCTURE; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME ASSAY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING; ANIMAL; BINDING SITE; CHEMISTRY; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

MURINAE;

ANIMALS; ANTIBODIES, MONOCLONAL; BINDING SITES; CARRIER PROTEINS; CREATINE KINASE; CRYSTALLOGRAPHY, X-RAY; HEAT-SHOCK PROTEINS; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; MOLECULAR CHAPERONES; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION;

EID: 0035793626     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M005221200     Document Type: Article

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