Propranolol affects stress-induced leukocytosis and cellular adhesion molecule expression

European Journal of Applied Physiology

Volumn 86, Issue 2, 2001, Pages 135-141

  Kühlwein, Eva C ^b   Irwin, Michael R ^b   Ziegler, Michael G ^b   Woods, Virgil L ^b   Kennedy, Brian ^b   Mills, Paul J ^a,b  

^a UCSD MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cell adhesion molecules; Exercise; Lymphocytes; Propranolol; Stress

Indexed keywords

ADRENALIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA1 INTEGRIN; CD4 ANTIGEN; CD8 ANTIGEN; CELL ADHESION MOLECULE; INTERCELLULAR ADHESION MOLECULE 1; L SELECTIN; LYMPHOCYTE ANTIGEN; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; NORADRENALIN; PADGEM PROTEIN; PLACEBO; PROPRANOLOL; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ADULT; ARTICLE; BICYCLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; CYTOTOXIC T LYMPHOCYTE; DENSITY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EXERCISE; HELPER CELL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LEUKOCYTE COUNT; LEUKOCYTOSIS; LYMPHOCYTE COUNT; MENTAL STRESS; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPEECH; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VOLUNTEER;

ADRENERGIC BETA-ANTAGONISTS; ADULT; CELL ADHESION MOLECULES; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; EXERCISE; HEART RATE; HORMONES; HUMANS; LEUKOCYTOSIS; LYMPHOCYTE COUNT; MONOCYTES; PROPRANOLOL; STRESS, PSYCHOLOGICAL;

EID: 0035787233     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-001-0526-8     Document Type: Article

References (29)

1. Ahlborg B, Ahlborg G (1970) Exercise leukocytosis with and without beta-adrenergic blockade. Acta Med Scand 187:241-246
2. Bachen E, Manuck S, Cohen S, Muldoon M, Raible R, Herbert T (1995) Adrenergic blockade ameliorates cellular immune responses to mental stress in humans. Psychosom Med 57:366-372
3. Benschop R, Nieuwenhuis E, Tromp E, Godaert G, Ballieux R, van Doornen LJ (1994) Effects of beta-adrenergic blockade on immunologic and cardiovascular changes induced by mental stress. Circulation 89:762-769
4. Benschop R, Rodriguez-Feuerhahn M, Schedlowski M (1996a) Catecholamine-induced leukocytosis: early observations, current research, and future directions. Brain Behav Immun 10:77-91
5. Benschop R, Jacobs R, Sommer B, Schürmeyer T, Raab J, Schmidt R, et al (1996b) Modulation of the immunologic response to acute stress in humans by beta-blockade or benzodiazepines. FASEB J 10:517-524
6. Benschop R, Schedlowski M, Wienecke H, Jacobs R, Schmidt RE (1997) Adrenergic control of natural killer cell circulation and adhesion. Brain Behav Immun 11:321-332
7. Carlson S, Beiting D, Kiani C, Abell K, McGillis DJP (1996) Catecholamines decrease lymphocyte adhesion to cytokine-activated endothelial cells. Brain Behav Immun 10:55-67
8. Gabriel HH, Kindermann W (1998) Adhesion molecules during immune response to exercise. Can J Physiol Pharmacol 76:512-523
9. Goebel M, Mills PJ (2000) Acute psychological stress and exercise and changes in peripheral leukocyte adhesion molecule expression and density. Psychosom Med 62:664-670
10. Goldstein S (1997) Beta-blocking drugs and coronary heart disease. Cardiovasc Drugs Ther 11:S219-S225
11. Gottlieb SS, McCarter RJ, Vogel R (1998) Effect of beta-blockade on mortality among high-risk and low-risk patients after myocardial infarction [see comments]. New Engl J Med 339:489-947
12. Kaplan JR, Manuck SB, Adams M, Weingand KW, Clarkson TB (1987) Inhibition of coronary atherosclerosis by propranolol in behaviorally predisposed monkeys fed an atherogenic diet. Circulation 76:1364-1372
13. Kennedy B, Ziegler M (1990) A more sensitive and specific radioenzymatic assay for catecholamines. Life Sci 47:2143-2153
14. Kindermann W, Schnabel A, Schmitt WM, Biro G, Cassens J, Weber F (1982) Catecholamines, growth hormone, cortisol, insulin, and sex hormones in anaerobic and aerobic exercise. Eur J Appl Physiol 49:389-399
15. Kurokawa Y, Shinkai S, Torii J, Hino S, Shek PN (1995) Exercise-induced changes in the expression of surface adhesion molecules on circulating granulocytes and lymphocytes subpopulations. Eur J Appl Physiol 71:245-252
16. Landmann RM, Müller FB, Perini C, Wesp M, Erne P, Bühler F (1984) Changes of immunoregulatory cells induced by psychological and physical stress: relationship to plasma catecholamines. Clin Exp Immunol 58:127-135
17. Lechat P, Packer M, Chalon S, Cucherat M, Arab T, Boissel JP (1998) Clinical effects of beta-adrenergic blockade in chronic heart failure: a meta-analysis of double-blind, placebo-controlled, randomized trials [see comments]. Circulation 98:1184-1191
18. Maisel A, Knowlton KU, Fowler P, Rearden A, Ziegler MG, Motulsky H (1990) Adrenergic control of circulating lymphocyte subpopulations. Effects of congestive heart failure, dynamic exercise, and terbutaline treatment. J Clin Invest 85:462-467
19. Miles MP, Leach S, Kraemer WJ, Dohi K, Bush J, Mastro A (1998) Leukocyte adhesion molecule expression during intense resistance exercise. J Appl Physiol 84:1604-1609
20. Mills P, Nelesen R, Ziegler M, Parry B, Berry C, Dillon E (1996) Menstrual cycle effects on catecholamine and cardiovascular responses to acute stress in black but not white normotensive women. Hypertension 27:962-967
21. Mills P, Karnik R, Dillon E (1997) L-selectin expression affects T-cell circulation following isoproterenol infusion in humans. Brain Behav Immun 11:333-423
22. Mills P, Rehman J, Ziegler M, Carter S, Dimsdale J, Maisel A (1999) Nonselective beta blockade attenuates the recruitment of CD62L(-)T lymphocytes following exercise. Eur J Appl Pbysiol 79:531-534
23. Mills P, Goebel M, Rehman J, Irwin M, Maisel A (2000) Leukocyte adhesion molecule expression and T cell naive/memory status following isoproterenol infusion. J Neuroimmunol 102:137-144
24. Murray DR, Irwin M, Rearden C, Ziegler M, Motulsky H, Maisel AS (1992) Sympathetic and immune interactions during dynamic exercise. Mediation via a beta 2-adrenergic-dependent mechanism. Circulation 86:203-213
25. Nie Q, Fan J, Haraoka S, Shimokama T, Watanabe T (1997) Inhibition of mononuclear cell recruitment in aortic intima by treatment with anti-ICAM-1 and anti-LFA-1 monoclonal antibodies in hypercholesterolemic rats: implications of the ICAM-1 and LFA-1 pathway in atherogenesis. Lab Invest 77:469-482
26. Rehman J, Mills P, Carter S, Chou J, Thomas J, Maisel A (1997) Dynamic exercise leads to an increase in circulating ICAM-1: further evidence for adrenergic modulation of cell adhesion. Brain Behav Immun 11:343-351
27. Rogers C, Edelman E, Simon DI (1998) A mAb to the beta2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbits. Proc Natl Acad Sci U S A 95:10134-10139
28. Watanabe T, Fan J (1998) Atherosclerosis and inflammation mononuclear cell recruitment and adhesion molecules with reference to the implication of ICAM-l/LFA-1 pathway in atherogenesis. Int J Cardiol 66:S45-S53
29. Ziegler M (1980) Postural hypotension. Ann Rev Med 31:239-245