Phosphorylation of voltage-gated ion channels in rat olfactory receptor neurons

European Journal of Neuroscience

Volumn 14, Issue 7, 2001, Pages 1056-1064

  Wetzel, Christian H ^a   Spehr, Marc ^a   Hatt, Hanns ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Adaptation; cAMP; cAMP dependent protein kinase (PKA); Olfaction; Signal transduction

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; CALCIUM CHANNEL; CALCIUM ION; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; DOPAMINE 1 RECEPTOR STIMULATING AGENT; SEROTONIN; SODIUM CHANNEL; SODIUM ION;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; ENZYME ACTIVATION; NEUROMODULATION; NONHUMAN; ODOR; OLFACTORY RECEPTOR; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; SENSORY NERVE CELL; SIGNAL TRANSDUCTION;

ANIMALS; BARIUM; CALCIUM CHANNELS; CELLS, CULTURED; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENZYME INHIBITORS; FORSKOLIN; ION CHANNELS; MALE; MEMBRANE POTENTIALS; NEUROTRANSMITTER AGENTS; ODORS; OLFACTORY RECEPTOR NEURONS; PATCH-CLAMP TECHNIQUES; PEPTIDES; PHOSPHORYLATION; RATS; RATS, WISTAR; RECEPTORS, NEUROTRANSMITTER; RECEPTORS, ODORANT; SIGNAL TRANSDUCTION; SMELL; SODIUM CHANNELS;

EID: 0035783452     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816X.2001.01722.x     Document Type: Article

References (49)

1. Balasubramanian, S., Lynch, J.W. & Barry, P.H. (1996) Calcium-dependent modulation of the agonist affinity of the mammalian olfactory cyclic nucleotide-gated channel by calmodulin and a novel endogenous factor. J. Mem. Biol., 152, 13-23.
2. Boekhoff, I. & Breer, H. (1992) Termination of second messenger signaling in olfaction. Proc. Natl. Acad. Sci. USA, 89, 471-474.
3. Boekhoff, I., Schleicher, S. & Strotmann, J. (1992) Odor-induced phosphorylation of olfactory cilia proteins. Proc. Natl. Acad. Sci. USA, 89, 11983-11987.
4. Borisy, F.F., Ronnett, G.V., Cunningham, A.M., Juilfs, D. & Beavo, J.S. (1992) Calcium/calmodulin-activated phosphodiesterase expressed in olfactory receptor neurons. J. Neurosci., 12, 915-923.
5. Buck, L.B. (1996) Information coding in the vertebrate olfactory system. Annu. Rev. Neurosci., 19, 517-544.
6. Buck, L. & Axel, R. (1991) A novel multigene family may encode odorant receptors: A molecular basis for odor recognition. Cell, 65, 175-187.
7. 2+-calmodulin of cyclic nucleotide-activated channel of rat olfactory receptor neurons. Nature, 368, 545-548.
8. Coronas, V., Krantic, S., Jourdan, F. & Moyse, E. (1999) Dopamine receptor coupling to adenylyl cyclase in rat olfactory pathway: A combined pharmacological-radioautographic approach. Neuroscience, 90, 69-78.
9. Coronas, V., Srivastava, L.K., Liang, J.J., Jourdan, F. & Moyse, E. (1997) Identification and localization of dopamine receptor subtypes in rat olfactory mucosa and bulb: A combined in situ hybridization and ligand binding radioautographic approach. J. Chem. Neuroanat., 12, 243-257.
10. Dawson, T.M., Arriza, J.L., Jaworsky, D.E., Borisy, F.F., Attramadal, H., Lefkowitz, R.J. & Ronnett, G.V. (1993) Beta-adrenergig receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization. Science, 259, 825-829.
11. Hamill, O.P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F.J. (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch. Eur. J. Physiol., 391, 85-100.
12. Hatt, H., Gisselmann, G. & Wetzel, C.H. (1999) Cloning, functional expression and characterization of a human olfactory receptor. Cell. Mol. Biol., 45, 285-291.
13. 2+ currents in olfactory receptor cells by shifting their inactivation curves to a negative voltage. Neurosci. Res., 35, 253-263.
14. Kawai, F., Kurahashi, T. & Kaneko, A. (1997) Nonselective suppression of voltage-gated currents by odorants in the newt olfactory receptor cells. J. Gen. Physiol., 419, 177-192.
15. Kawai, F. & Miyachi, E. (2000) Direct suppression by odorants of cyclic nucleotide-gated currents in the newt photoreceptors. Brain Res., 876, 180-184.
16. Kawano, T. & Margolis, F. (1985) Catecholamines in olfactory mucosa decline following superior cervical ganglionectomy. Chem. Sens., 10, 353-356.
17. Kleene, S.J. & Gesteland, R.C. (1991) Calcium-activated chloride conductance in frog olfactory cilia. J. Neurosci., 11, 3624-3629.
18. 2+ regulates the sensitivity of cyclic nucleotide-gated channels in olfactory receptor neurons. Neuron, 9, 897-906.
19. Kurahashi, T., Lowe, G. & Gold, G.H. (1994) Suppression of odorant responses by odorants in olfactory receptor cells. Science, 265, 118-120.
20. Kurahashi, T. & Menini, A. (1997) Mechanism of odorant adaptation in the olfactory receptor cell. Nature, 385, 725-729.
21. Kurahashi, T. & Yau, K.W. (1994) Olfactory transduction. Tale of an unusual chloride current. Curr. Biol., 4, 256-258.
22. Lancet, D., Ben-Arie, N., Cohen, S., Gat, U., Gross-Isseroff, R., Khen, M., Lehrach, H., Natochin, M. & North, M. (1993) Olfactory receptors: Transduction, diversity, human psychophysics and genome analysis. CIBA Foundation Symp., 179, 131-141.
23. 2+/calmodulin kinase II. J. Neurosci., 19, 1-6.
24. + conductance in rat olfactory neurons. J. Neurophysiol., 82, 226-236.
25. Lynch, J.W. & Lindemann, B. (1994) Cyclic nucleotide-gated channels of rat olfactory receptor cells: Divalent cations control the sensitivity to cAMP. J. Gen. Physiol., 103, 87-106.
26. Malnic, B., Hirono, J., Sato, T. & Buck, L.B. (1999) Combinatorial receptor codes for odors. Cell, 96, 713-723.
27. 2 receptor agonist, inhibits adenylyl cyclase activity in rat olfactory epithelium. Neuroscience, 57, 173-180.
28. Mombaerts, P. (1999) Seven-transmembrane proteins as odorant and chemosensory receptors. Science, 286, 707-711.
29. Moon, C., Jaberi, P., Otto-Bruc, A., Baehr, W., Palczewski, K. & Ronnett, G.V. (1998) Calcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neurons. J. Neurosci., 18, 3195-3205.
30. Moon, C., Sung, Y.-K., Reddy, R. & Ronnett, G.V. (1999) Odorants induce the phosphorylation of the cAMP response element binding protein in olfactory receptor neurons. Proc. Natl. Acad. Sci. USA, 96, 14605-14610.
31. Mori, K. & Yoshihara, Y. (1995) Molecular recognition and olfactory processing in the mammalian olfactory system. Prog. Neurobiol., 45, 585-619.
32. Müller, F., Bonigk, W., Sesti, F. & Frings, S. (1998) Phosphorylation of mammalian olfactory cyclic nucleotide-gated channels increases ligand sensitivity. J. Neurosci., 18, 164-173.
33. Peppel, K., Boekhoff, I., McDonald, P., Caron, M.G. & Lefkowitz, R.J. (1997) G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. J. Biol. Chem., 272, 25425-25428.
34. Qu, W., Moorhouse, A.J., Rajendra, S. & Barry, P.H. (2000) Very negative potential for half-inactivation of, and effects of anions on, voltage-dependent dodium currents in acutely isolated rat olfactory receptor neurons. J. Mem. Biol., 175, 123-138.
35. Reed, R.R. (1992) Signaling pathways in odorant detection. Neuron, 8, 205-209.
36. Sanhueza, M., Schmachtenberg, O. & Bacigalupo, J. (2000) Excitation, inhibition, and suppression by odors in isolated toad and rat olfactory receptor neurons. Am. J. Physiol. Cell Physiol., 279, C31-39.
37. 1 receptor modulates the voltage-gated sodium current in rat striatal neurones through a protein kinase A. J. Physiol., 483, 95-107.
38. Shepherd, G.M. (1994) Discrimination of molecular signals by the olfactory receptor neuron. Neuron, 13, 771-790.
39. Smith, R.D. & Goldin, A.L. (1996) Phosphorylation of brain sodium channels in the I - II linker modulates channel function in Xenopus oocytes. J. Neurosci., 16, 1965-1974.
40. Smith, R.D. & Goldin, A.L. (1997) Phosphorylation at a single site in the rat brain sodium channel is necessary and sufficient for current reduction by protein kinase A. J. Neurosci., 17, 6086-6093.
41. Touhara, K., Sengoku, S., Inaki, K., Tsuboi, A., Hirono, J., Sato, T., Sakano, H. & Haga, T. (1999) Functional identification and reconstitution of an odorant receptor in single olfactory neurons. Proc. Natl. Acad. Sci. USA, 96, 4040-4045.
42. h in cultured rat olfactory receptor neurons. J. Neurophysiol., 81, 149-158.
43. 2+ oscillations in HEK-293 cells. J. Biol. Chem., 270, 24108-24115.
44. Wei, J., Wayman, G. & Storm, D.R. (1996) Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo. J. Biol. Chem., 271, 24231-24235.
45. Wei, J., Zhao, A.Z., Chan, G.C., Baker, L.P., Impey, S., Beavo, J.A. & Storm, D.R. (1998) Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in neurons: A mechanism for attenuation of olfactory signals. Neuron, 21, 495-504.
46. Wetzel, C.H., Hermann, B., Behl, C., Pestel, E.K., Rammes, G., Zieglgänsberger, W., Holsboer, F. & Rupprecht, R. (1998) Functional antagonism of gonadal steroids at the 5-hydroxytryptamine type 3 receptor. Mol. Endocrinol., 12, 1441-1451.
47. Wetzel, C.H., Oles, M., Wellerdieck, C., Kuczkowiak, M., Gisselmann, G. & Hatt, H. (1999) Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus Laevis oocytes. J. Neurosci., 19, 7426-7433.
48. Zufall, F. & Leinders-Zufall, T. (1997) Identification of a long-lasting form of odor adaptation that depends on the carbon monoxide/cGMP second-messenger system. J. Neurosci., 17, 2703-2712.
49. Zufall, F. & Leinders-Zufall, T. (1998) Role of cyclic GMP in olfactory transduction and adaptation. Ann. NY Acad. Sci., 855, 199-204.