Review: Cellular substrates of the eukaryotic chaperonin TRiC/CCT

Journal of Structural Biology

Volumn 135, Issue 2, 2001, Pages 176-184

  Dunn, Alice Y ^a   Melville, Mark W ^a   Frydman, Judith ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CHAPERONIN; CYTOSKELETON PROTEIN; POLYPEPTIDE; PROTEIN; TUBULIN;

BIOCHEMISTRY; CYTOSOL; EUKARYOTE; GENETIC ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FOLDING; REVIEW; SPECTRUM;

EUKARYOTA;

EID: 0035783192     PISSN: 10478477     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsbi.2001.4380     Document Type: Review

References (70)

1. Bukau, B., Deuerling, E., Pfund, C., and Craig, E. A. (2000) Getting newly synthesized proteins into shape, Cell 101, 119-122.
2. Bukau, B., and Horwich, A. L. (1998) The Hsp70 and Hsp60 chaperone machines, Cell 92, 351-366.
3. Chen, F., Kishida, T., Yao, M., Hustad, T., Glavac, D., Dean, M., Gnarra, J. R., Orcutt, M. L., Duh, F. M., Glenn, G., et al. (1995) Germline mutations in the von Hippel-Lindau disease tumor suppressor gene: Correlations with phenotype, Hum Mutat. 5, 66-75.
4. Chen, X., Sullivan, D. S., and Huffaker, T. C. (1994) Two yeast genes with similarity to TCP-1 are required for microtubule and actin function in vivo, Proc. Natl. Acad. Sci. USA 91, 9111-9115.
5. Clurman, B. E., Sheaff, R. J., Thress, K., Groudine, M., and Roberts, J. M. (1996) Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation, Genes Dev. 10, 1979-1990.
6. Ditzel, L., Lowe, J., Stock, D., Stetter, K. O., Huber, H., Huber, R., and Steinbacher, S. (1998) Crystal structure of the thermosome, the archaeal chaperonin and homolog of CCT, Cell 93, 125-138.
7. Dobrzynski, J., Sternlicht, M., Farr, G., and Sternlicht, H. (1996) Newly-synthesized beta-tubulin demonstrates domain-specific interactions with the cytosolic chaperonin, Biochemistry 35, 15870-15882.
8. Ewalt, K. L., Hendrick, J. P., Houry, W. A., and Hartl, F. U. (1997) In vivo observation of polypeptide flux through the bacterial chaperonin system, Cell 90, 491-500.
9. Farr, G. W., Scharl, E. C., Schumacher, R. J., Sondek, S., and Horwich, A. L. (1997) Chaperonin-mediated folding in the eukaryotic cytosol proceeds through rounds of release of native and nonnative forms, Cell 89, 927-937.
10. Feldman, D. E., and Frydman, J. (2000) Protein folding in vivo: The importance of molecular chaperones, Curr. Opin. Struct. Biol. 10, 26-33.
11. Feldman, D. E., Thulasiraman, V., Ferreyra, R. G., and Frydman, J. (1999) Formation of the VHL-Elongin BC tumor suppressor complex is mediated by the chaperonin TRiC, Mol. Cell 4, 1051-1061.
12. Frydman, J., and Hartl, F. U. (1996) Principles of chaperone-assisted protein folding: Differences between in vitro and in vivo mechanisms, Science 272, 1497-1502.
13. Frydman, J., Nimmesgern, E., Erdjument, B. H., Wall, J. S., Tempst, P., and Hartl, F. U. (1992) Function in protein folding of TRiC, a cytosolic ring complex containing TCP-1 and structurally related subunits, EMBO J. 11, 4767-4778.
14. Frydman, J., Nimmesgem, E., Ohtsuka, K., and Hartl, F. U. (1994) Folding of nascent polypeptide chains in a high molecular mass assembly with molecular chaperones, Nature 370, 111-117.
15. Gao, Y., Thomas, J. O., Chow, R. L., Lee, G. H., and Cowan, N. J. (1992) A cytoplasmic chaperonin that catalyzes beta-actin folding, Cell 69, 1043-1050.
16. Geissler, S., Siegers, K., and Schiebel, E. (1998) A novel protein complex promoting formation of functional alpha- and gamma-tubulin, EMBO J. 17, 952-966.
17. Gnarra, J. R., Tory, K., Weng, Y., Schmidt, L., Wei, M. H., Li, H., Latif, F., Liu, S., Chen, F., Duh, F. M., et al. (1994) Mutations of the VHL tumour suppressor gene in renal carcinoma, Nat. Genet. 7, 85-90.
18. Gutsche, I., Essen, L. O., and Baumeister, W. (1999) Group II chaperonins: New TRiC(k)s and turns of a protein folding machine, J. Mol. Biol. 293, 295-312.
19. Hansen, W. J., Cowan, N. J., and Welch, W. J. (1999) Prefoldinnascent chain complexes in the folding of cytoskeletal proteins, J. Cell Biol. 145, 265-277.
20. Hansen, W. J., Lingappa, V. R., and Welch, W. J. (1994) Complex environment of nascent polypeptide chains, J. Biol. Chem. 269, 26610-26613.
21. Hartl, F. U. (1996) Molecular chaperones in cellular protein folding, Nature 381, 571-579.
22. Houry, W. A., Frishman, D., Eckerskorn, C., Lottspeich, F., and Hartl, F. U. (1999) Identification of in vivo substrates of the chaperonin GroEL, Nature 402, 147-154.
23. Hynes, G. M., and Willison, K. R. (2000) Individual subunits of the eukaryotic cytosolic chaperonin mediate interactions with binding sites located on subdomains of beta-actin, J. Biol. Chem. 275, 18985-18994.
24. James, P., Pfund, C., and Craig, E. A. (1997) Functional specificity among Hsp70 molecular chaperones, Science 275, 387-389.
25. Kaelin, W. G. (1999) Cancer: Many vessels, Faulty gene, Nature 399, 203-204.
26. Kamura, T., Sato, S., Iwai, K., CzyzykKrzeska, M., Conaway, R. C., and Conaway, J. W. (2000) Activation of HIF1 alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex, Proc. Natl. Acad. Sci. USA 97, 10430-10435.
27. Kashuba, E., Pokrovskaja, K., Klein, G., and Szekely, L. (1999) Epstein-Barr virus-encoded nuclear protein EBNA-3 interacts with the epsilon-subunit of the T-complex protein 1 chaperonin complex, J. Hum. Virol. 2, 33-37.
28. Kibel, A., Iliopoulos, O., DeCaprio, J. A., Kaelin, W. G. Jr. (1995) Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C, Science 269, 1444-1446.
29. Kim, S., Willison, K. R., and Horwich, A. L. (1994) Cystosolic chaperonin subunits have a conserved ATPase domain but diverged polypeptide-binding domains, Trends Biochem. Sci. 19, 543-548.
30. Klumpp, M., Baumeister, W., and Essen, L. O. (1997) Structure of the substrate binding domain of the thermosome, an archaeal group II chaperonin, Cell 91, 263-270.
31. Koff, A., Cross, F., Fisher, A., Schumacher, J., Leguellec, K., Philippe, M., and Roberts, J. M. (1991) Human cyclin-E; a new cyclin that interacts with 2 members of the Cdc2 gene family, Cell 66, 1217-1228.
32. Latif, F., Tory, K., Gnarra, J., Yao, M., Duh, F. M., Orcutt, M. L., Stackhouse, T., Kuzmin, I., Modi, W., Geil, L., et al. (1993) Identification of the von Hippel-Lindau disease tumor suppressor gene, Science 260, 1317-1320.
33. Lewis, V. A., Hynes, G. M., Zheng, D., Saibil, H., and Willison, K. (1992) T-complex polypeptide-1 is a subunit of a heteromeric particle in the eukaryotic cystosol, Nature 358, 249-252.
34. Linehan, W. M., Lerman, M. I., and Zbar, B. (1995) Identification of the von Hippel-Lindau (VHL) gene: Its role in renal cancer, J. Am. Med. Assoc. 273, 564-570.
35. Lingappa, J. R., Martin, R. L., Wong, M. L., Ganem, D., Welch, W. J., and Lingappa, V. R. (1994) A eukaryotic cytosolic chaperonin is associated with a high molecular weight intermediate in the assembly of hepatitis B virus capsid, a multimeric particle, J. Cell Biol. 125, 99-111.
36. Llorca, O., MartinBenito, J., RitcoVonsovici, M., Grantham, J., Hynes, G. M., Willison, K. R., Carrascosa, J. L., and Valpuesta, J. M. (2000) Eukaryotic chaperonin CCT stabilizes actin and tubulin folding intermediates in open quasi-native conformations, EMBO J. 19, 5971-5979.
37. Llorca, O., McCormack, E. A., Hynes, G., Grantham, J., Cordell, J., Carrascosa, J. L., Willison, K. R., Fernandez, J. J., and Valpuesta, J. M. (1999) Eukaryotic type II chaperonin CCT interacts with actin through specific subunits, Nature 402, 693-696.
38. Lonergan, K. M., Iliopoulos, O., Ohh, M., Kamura, T., Conaway, R. C., Conaway, J. W., and Kaelin, W. G., Jr. (1998) Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2, Mol. Cell. Biol. 18, 732-741.
39. Maher, E. R., and Kaelin, W. G., Jr. (1997) Von Hippel-Lindau disease, Medicine 76, 381-391.
40. Maxwell, P. H., Wiesener, M. S., Chang, G. W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., and Ratcliffe, P. J. (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis, Nature 399, 271-275.
41. Mayhew, M., da Silva, A. C. R., Martin, J., Erdjument-Bromage, H., Tempst, P., and Hartl, F. U. (1996) Protein folding in the central cavity of the GroEL-GroES chaperonin complex. Nature 379, 420-425.
42. McCallum, C. D., Do, H., Johnson, A. E., and Frydman, J. (2000) The interaction of the chaperonin tailless complex polypeptide 1 (TCP1) ring complex (TRiC) with ribosome-bound nascent chains examined using photo-cross-linking, J. Cell Biol. 149, 591-601.
43. Melki, R., Batelier, G., Soulie, S., and Williams, R. C., Jr. (1997) Cytoplasmic chaperonin containing TCP-1: Structural and functional characterization, Biochemistry 36, 5817-5826.
44. Melki, R., Vainberg, I. E., Chow, R. L., and Cowan, N. J. (1993) Chaperonin-mediated folding of vertebrate actin-related protein and gamma-tubulin, J. Cell Biol. 122, 1301-1310.
45. Ohh, M., Yauch, R. L., Lonergan, K. M., Whaley, J. M., Stemmerrachamimov, A. O., Louis, D. N., Gavin, B. J., Kley, N., Kaelin, W. G., and Iliopoulos, O. (1998) The Von-Hippel-Lindau tumor-suppressor protein is required for proper assembly of an extracellular fibronectin matrix, Mol. Cell 1, 959-968.
46. Ohh, M., Park, C. W., Ivan, N., Hoffman, M. A., Kim, T. Y., Huang, L. E., Pavletich, N., Chau, V., and Kaelin, W. G. (2000) Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein, Nat. Cell Biol. 2, 423-427.
47. Pause, A., Lee, S., Lonergan, K. M., and Klausner, R. D. (1998) The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal, Proc. Natl. Acad. Sci. USA 95, 993-998.
48. Pedersen, S. (1984) Escherichia coli ribosomes translate in vivo with variable rate. EMBO J. 3, 2895-2898.
49. Pfund, C., Lopezhoyo, N., Ziegelhoffer, T., Schilke, B. A., Lopezbuesa, P., Walter, W. A., Wiedmann, M., and Craig, E. A. (1998) The molecular chaperone Ssb from Saccharomyces cerevisiae is a component of the ribosome nascent chain complex, EMBO J. 17, 3981-3989.
50. RitcoVonsovici, M., and Willison, K. R. (2000) Defining the eukaryotic cytosolic chaperonin-binding sites in human tubulins. J. Mol. Biol. 304, 81-98.
51. Rommelaere, H., De Neve, M., Melki, R., Vandekerckhove, J., and Ampe, C. (1999) The cytosolic class II chaperonin CCT recognizes delineated hydrophobic sequences in its target proteins, Biochemistry 38, 3246-3257.
52. Roobol, A., and Carden, M. J. (1999) Subunits of the eukaryotic cytosolic chaperonin CCT do not always behave as components of a uniform hetero-oligomeric particle, Eur. J. Cell Biol. 78, 21-32.
53. Shuin, T., Kondo, K., Torigoe, S., Kishida, T., Kubota, Y., Hosaka, M., Nagashima, Y., Kitamura, H., Latif, F., Zbar, B., et al. (1994) Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas, Cancer Res. 54, 2852-2855.
54. Siegers, K., Waldmann, T., Leroux, M. R., Grein, K., Shevchenko, A., Schiebel, E., and Hartl, F. U. (1999) Compartmentation of protein folding in vivo: Sequestration of non-native polypeptide by the chaperonin-GimC system, EMBO J. 18, 75-84.
55. Siegert, R., Leroux, M. R., Scheufler, C., Hartl, F. U., and Moarefi, I. (2000) Structure of the molecular chaperone prefoldin: Unique interaction of multiple coiled coil tentacles with unfolded proteins, Cell 103, 621-632.
56. Srikakulam, R., and Winkelmann, D. A. (1999) Myosin II folding is mediated by a molecular chaperonin, J. Biol. Chem. 274, 27265-27273.
57. Stebbins, C. E., Kaelin, W. G. Jr., and Pavletich, N. P. (1999) Structure of the VHL-ElonginC-ElonginB complex: Implications for VHL tumor suppressor function, Science 284, 455-461.
58. Sternlicht, H., Farr, G. W., Sternlicht, M. L., Driscoll, J. K., Willison, K., and Yaffe, M. B. (1993) The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo, Proc. Natl. Acad. Sci. USA 90, 9422-9426.
59. Tanimoto, K., Makino, Y., Pereira, T., and Poellinger, L. (2000) Mechanism of regulation of the hypoxia-inducible factor-I alpha by the von Hippel-Lindau tumor suppressor protein, EMBO J. 19, 4298-4309.
60. Thulasiraman, V., Yang, C. F., and Frydman, J. (1999) In vivo newly translated polypeptides are sequestered in a protected folding environment, EMBO J. 18, 85-95.
61. Tian, G. L., Vainberg, I. E., Tap, W. D., Lewis, S. A., and Cowan, N. J. (1995) Specificity in chaperonin-mediated protein folding, Nature 375, 250-253.
62. Vainberg, I. E., Lewis, S. A., Rommelaere, H., Ampe, C., Vandekerckhove, J., Klein, H. L., and Cowan, N. J. (1998) Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin, Cell 93, 863-873.
63. Vinh, D. B., and Drubin, D. G. (1994) A yeast TCP-1-like protein is required for actin function in vivo, Proc. Natl. Acad. Sci. USA 91, 9116-9120.
64. Wang, S., Sakai, H., and Wiedmann, M. (1995) NAC covers ribosome-associated nascent chains thereby forming a protective environment for regions of nascent chains just emerging from the peptidyl transferase center, J. Cell Biol. 130, 519-528.
65. Weissman, J. S., Rye, H. S., Fenton, W. A., Beechem, J. M., and Horwich, A. L. (1996) Characterization of the active intermediate of a GroEL-GroES-mediated protein folding reaction, Cell 84, 481-490.
66. Willison, K. R., and Horwich, A. L. (1996) Structure and function of chaperonins in archaebacteria and eukaryotic cytosol, in Ellis, R. J. (Ed.), Cell Biology Series: The Chaperonins, pp. 107-136, Academic Press, London/San Diego.
67. Wittinghofer, A. (1994) The structure of transducin-G(Alpha-T): More to view than just Ras, Cell 76, 201-204.
68. Won, K. A., Schumacher, R. J., Farr, G. W., Horwich, A. L., and Reed, S. I. (1998) Maturation of human cyclin E requires the function of eukaryotic chaperonin CCT, Mol. Cell. Biol. 18, 7584-7589.
69. Yaffe, M. B., Farr, G. W., Miklos, D., Horwich, A. L., Stemlicht, M. L., and Sternlicht, H. (1992) TCP1 complex is a molecular chaperone in tubulin biogenesis, Nature 358, 245-248.
70. Yan, W., Schilke, B., Pfund, C., Walter, W., Kim, S. W., and Craig, E. A. (1998) Zuotin: A ribosome-associated DnaJ molecular chaperone, EMBO J. 17, 4809-4817.