Development and application of a focused ultrasoft X-ray probe for radiobiological applications

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 4499, Issue , 2001, Pages 10-18

  Folkard, Melvyn ^a   Schettino, Giuseppi ^a   Vojnovic, Boris ^a   Michette, Alan G ^b   David, Christian ^c   Pfauntsch, Slawka J ^b   Prise, Kevin M ^a   Michael, Barry D ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c PAUL SCHERRER INSTITUTE   (Switzerland)

Author keywords

Bystander effect; Cells; Characteristic X rays; Microprobe; Radiobiology; Ultrasoft X rays

Indexed keywords

BIOLOGICAL RADIATION EFFECTS; CELLS; PROBES; TISSUE;

BYSTANDER EFFECT; MICROPROBES; RADIOBIOLOGY; ULTRASOFT X RAYS;

X RAY OPTICS;

EID: 0035765639     PISSN: 0277786X     EISSN: None     Source Type: Journal    
DOI: 10.1117/12.450232     Document Type: Article

References (22)

1. R.E. Zirkle, and W. Bloom, "Irradiation of parts of cells", Science, 117, pp487-493, 1953.
2. M. Folkard, B. Vojnovic, K. M. Prise, A. G. Bowey, R. J. Locke, G. Schettino and B. D. Michael, "A charged-particle microbeam I. Development of an experimental system for targeting cells individually with counted particles", Int. J. Radiat. Biol., 72, pp. 375-385, 1997.
3. M. Folkard, B. Vojnovic, K. J. Hollis, A. G. Bowey, S. J. Watts, G. Schettino, K. M. Prise and B. D. Michael, "A charged particle microbeam: II A single-particle micro-collimation and detection system", Int. J. Radiat. Biol., 72, pp. 387-395, 1997.
4. C. Geard, D.J. Brenner, G. Randers-Pehrson and S.A. Marino, "Single-particle irradiation of mammalian cells at the Radiological Research Accelerator Facility: induction of chromosomal changes", Nucl. Instr. Meth. B54, pp.411-416, 1991.
5. M. Folkard, K. M. Prise, B. Vojnovic, S. Gilchrist, G. Schettino, O. V. Belyakov, A. Ozols and B. D. Michael, The impact of microbeams in radiation biology. "Proc. 7th Int. Conf. on Microprobe Technology and Applications", Nucl. Instr. Meth. 2001. In press.
6. C. A. MacDonald and W. M. Gibson, "X-Ray and Neutron Optics. In Handbook of Optics Vol III. Classical, Vision and X-Ray Optics", pp. 19.1-30.17, McGraw-Hill, New York, 2001.
7. H. Nagasawa, and J. B. Little, "Induction of sister chromatid exchanges by extremely low doses of α-particles", Cancer Res. 52, pp. 6394-6396, 1992.
8. A. Deshpande, E. H. Goodwin, S. M. Bailey, B. L. Marrone and B. E. Lehnert, "Alpha-particle-induced sister chromatid exchange in normal human lung fibroblasts: Evidence for an extranuclear target", Radiat. Res. 145, pp. 260-267, 1996.
9. A. W. Hickman, R. J. Jaramillo, J. F. Lechner, and N. F. Johnson, "α-particle-induced p53 expression in a rat lung epithelial cell strain. Cancer Res. 54, pp. 5797-5800, 1994.
10. H. Zhou, G. Randers-Pehrson, C. A. Waldren, D. Vannais, E. J. Hall, and T. K. Hei, "Induction of a bystander mutagenic effect of alpha particles in mammalian cells", Proc. Nat. Acad. Sci. USA, 97, pp. 2099-2104, 2000.
11. O. V. Belyakov, A. M. Malcolmson, M. Folkard, K. M. Prise and B. D. Michael, "Direct evidence for a radiation-induced bystander effect of ionising radiation in primary human fibroblasts", British J. Cancer, 84, pp. 674-679, 2001.
12. K. M. Prise, O. V. Belyakov, M. Folkard and B. D. Michael, "Studies of bystander effects in human fibroblasts using a charged particle microbeam", Int. J. Radiat. Biol., 74, pp. 793-798, 1998.
13. R. Datta, A. Cole and S. Robinson, "Use of track-end alpha particles from 241 Am to study radiosensitive sites in CHO cells", Radiat. Res., 65, pp. 139-151, 1976.
14. T. K. Hei, L. J. Wu, S. X. Liu, D. Vannais, C. A. Waldren and G. Randers-Pehrson, "Mutagenic effects of a single and an exact number of alpha particles in mammalian cells", Proc. Natl. Acad. Sci., 94, pp. 3765-3770, 1997.
15. A. Ozols, K.M. Prise, K. R. Trott, M. Folkard and B. D. Michael, "The role of oxidative stress and DNA damage in genomic instability: targeted microbeam studies in primary human fibroblasts", Radiat. Res., 153, pp. 229-230, 2000.
16. G. Schmahl, D. Rudolph, B. Neimann, P. Guttmann, J. Thieme, G. Schneider, C. David, M. Diehl and T. Wilhein, "X-ray microscopy studies", Optik pp. 95-102, 1993.
17. C. David, E. Deckard, F. Glaus, B. Haas, B. Ketterer, T. Neiger, B. Nöhammer and H. Solak, "Diffractive x-ray lenses for Photon energies ranging from 90 eV to 29,000 eV", this conference.
18. R. C. Miller, G. Randers-Pehrson, C. R. Geard, E. J. Hall and D. Brenner, "The oncogenic transforming potential of the passage of single alpha particles through mammalian cell nuclei", Proc. Natl. Acad. Sci., 96, pp. 19-22, 1999.
19. D. T. Goodhead, J. Thacker and R. Cox, "Effectiveness of 0.3 keV carbon ultrasoft X-rays for the inactivation and mutation of cultured mammalian cells", Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med., 36, pp. 101-114, 1979.
20. K. M. Prise, M. Folkard, S. Davies and B. D. Michael, "Measurement of DNA damage and cell killing in Chinese hamster V79 cells irradiated with aluminum characteristic ultrasoft X rays", Radiat. Res., pp. 117, 489-499, 1989.
21. B. Marples and M. C. Joiner, "The response of Chinese hamster V79 cells to low radiation doses: evidence of enhanced sensitivity of the whole cell population", Radiat. Res., 133, pp. 41-51, 1993.
22. M. C. Joiner, B. Marples, P. Lambin, S. C. Short, and I. Turesson, "Low-dose hypersensitivity: current status and possible mechanisms", Int. J. Radiat. Oncol. Biol. Phys., 49, pp. 379-389, 2001.