Brain 5HT2A receptor regulation by tryptophan supplementation in Streptozotocin diabetic rats

Journal of Biochemistry, Molecular Biology and Biophysics

Volumn 5, Issue 1, 2001, Pages 1-7

  James, Jackson ^a   Paulose, Cheramadathikudyil S ^a  

^a Department of Physics   (India)

Author keywords

5 HT2A receptor; Diabetes; Serotonin; Streptozotocin; Tryptophan

Indexed keywords

ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; GLUCOSE; INSULIN; KETANSERIN; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; STREPTOZOCIN; TRYPTOPHAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BRAIN CORTEX; BRAIN STEM; CONTROLLED STUDY; DIABETES MELLITUS; DISSOCIATION CONSTANT; DRUG ANTAGONISM; DRUG POTENTIATION; GLUCOSE BLOOD LEVEL; NONHUMAN; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; SCATCHARD PLOT; SUPPLEMENTATION;

EID: 0035760579     PISSN: 10258140     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Curzon G, Mursden CA. Metabolism of a tryptophan load in the hypothalamus and other brain regions. J. Neurochem 1975; 25: 251-256.
2. Friedman PA, Kappelman AG, Kautman S. Partial purification and characterisation of tryptophan hydroxylase from rabbit hind brain. J. Biol. Chem 1972; 247: 4165-4173.
3. DeMarte ML, Enescol H. Influence of diet on plasma tryptophan and brain serotonin levels in mice. Experientia 1985; 41: 48-50.
4. Fernstrom JD. Effect of the diet and other metabolic phenomena on brain tryptophan uptake and serotonin synthesis. Adv. Exp. Med. Biol 1991; 294: 369-376.
5. Fernstrom MH, Fernstrom JD. Brain tryptophan concentrations and serotonin synthesis remain responsive to food consumption after the ingestion of sequential meals. Am. J. Clin. Nutr. 1995; 61: 312-319.
6. Biggio G, Fudda F, Fanni D, Tagliamonte A, Gessa GL. Rapid depletion of serum tryptophan, brain tryptophan, serotonin and 5-hydroxyindole acetic acid by a tryptophan free diet. Life Sci 1974; 14: 1321-1329.
7. Madras BK, Cohen HL, Messing R, Munro HN, Wurtman RJ. Relevance of free tryptophan in serum to tissue tryptophan concentration. Metabolism 1974; 23: 1107-1116.
8. Trulson ME. Mackenzie Effects of insulin and streptozotocin induced diabetes on brain tryptophan and serotonin metabolism in rats. J Neurochem 1978; 30: 205-211.
9. Trulson ME, Jacoby J, MacKenzie RG. Streptozotocin induced diabetes reduces brain serotonin synthesis in rats. J Neurochem 1986; 46: 1068-1072.
10. Bellush LL, Reid SG. Altered behaviour and neurochemistry during short term insulin withdrawal in streptozotocin induced diabetic rats. Diabetes 1991; 40: 217-222.
11. Arison RN, Ciaccio EI, Glitzer MS, Cassaro AB, Pruss MP Light and electron microscopy of lesions in rats rendered diabetic with streptozotocin. Diabetes 1967; 16: 51-56.
12. Hohenegger M, Rudas B. Kidney function in experimental diabetic ketosis. Diabetologia 1971; 17: 334-338.
13. Sasaki S, Bunag RD. Insulin reverses hypertension and hypothalamic depression in streptozotocin diabetic rats. Hypertension 1983; L5: 34-40.
14. 3H]Dopa in various regions of the brain. J Neurochem 1966; 13: 655-669.
15. Paulose CS., Dakshinamurti K, Packer S. Stephens NL. Sympathetic stimulation and hypertension in pyridoxine deficient adult rat. Hypertension 1988; 11: 387-391.
16. 2+ antagonists and hydralazine on central 5-Hydroxytryptamine biochemistry and function in rats and mice. Br J Pharmacol 1990; 99: 41-46.
17. Lowry OH, Roserbrough NJ, Farr AL, Randall RJ. Protein measurement with Folin Phenol reagent. J Biol Chem 1951; 193: 265-275.
18. Unnerstall JR Computer analysis of binding data. In Methods in Neurotransmitter Receptor Analysis. ed. Yamamura, H., Enna, S. & Kuhar, M. Raven Press 1990 247-255.
19. Cheng Y, Prusoff WH. Relationship between the inhibition constant (Ki) and the concentration of an inhibitor that causes a 50% inhibition of an enzymatic reaction. Biochem Pharmacol 1973; 22: 3099-3108.
20. 2A receptors in rat brain. Life Sci 1997; 60: 1393-1397.
21. 2A receptors in cerebral cortex and brain stem of streptozotocin induced diabetic rats. Mol. Cell. Biochem 1999; 199: 81-85.
22. 2A receptors in the rat brain. Neuropsychopharm 1997; 16: 183-190.
23. Pizzinat N, Chen SLF, Remaury A, Morgan NG, Parini A. Characterization of monoamine oxidase isoforms in human islets of Langerhans. Life Science 1999; 65: 441-448.
24. Jamnicky B, Muck-Seler D, Slijepcevic M. Favourable effect of tryptophan/insulin treatment on serotoninergic imbalance in alloxan diabetic rats. Comp. Biochem. Physiol. Comp. Physiol 1993; 105: 267-273.
25. Rossi-Fanelli F. Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients. Int. J. Obes. Relat. Metab. Disord 1998; 22: 648-654.
26. Kwok RPS, Juorio AV. Facilitating effect of insulin on brain 5-hydroxytryptamine metabolism. Neuroendocrinol 1987; 45: 267-273.
27. 2 receptor agonists DOI and α-methyl 5-HT on plasma glucose and insulin levels in rat. Eur J Pharm 1990; 185: 11-18.
28. Stanley M. Increased serotonin binding sites in frontal cortex of suicide victims. Lancet 1983; 1: 1214-1216.
29. 2 and β-adrenergic receptor binding in the frontal cortices of suicide victims. Arch Gen Psychiatry 1986; 43: 954-959.
30. Fernstrom JD. Dietary amino acids and brain function. J. Am. Diet. Assoc 1994; 94: 71-77.
31. DeMarte ML, Enesco H. Influence of diet on plasma tryptophan and brain serotonin levels in mice. Experientia 1985; 41: 48-50.