Experimental Copper Deficiency, Chromium Deficiency and Additional Molybdenum Supplementation in Goats - Pathological Findings

Acta Veterinaria Scandinavica

Volumn 42, Issue 3, 2001, Pages 311-321

  Aupperle, H ^a   Schoon, H A ^a   Frank, A ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Histopathology; Liver; Molybdenosis; Moose; Pancreas

Indexed keywords

CHROMIUM; COPPER; MOLYBDENUM;

ANIMAL; ANIMAL DISEASE; ARTICLE; CHEMICALLY INDUCED DISORDER; GOAT; GOAT DISEASE; IMMUNOHISTOCHEMISTRY; LIVER; MALE; PANCREAS; PATHOLOGY; SKIN;

ANIMALS; CHROMIUM; COPPER; GOAT DISEASES; GOATS; IMMUNOHISTOCHEMISTRY; LIVER; MALE; MOLYBDENUM; PANCREAS; SKIN;

EID: 0035750137     PISSN: 0044605X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Anke M, Groppel B: Flourmangelerscheinungen bei der Ziege. (Signs of flourdeficiency in the goat.) In: Anke M. et al., (eds): Mengen- und Spurenelemente. Friedrich-Schiller-Universität, Jena, Germany. Leipzig: VEB Kongress- und Werbedruck Oberlurigwitz, 1989, 346-363.
2. Bandyopadhyay SK, Chatterjee K, Tiwari RK, Mitra A, Banerjee A, Ghosh KK, Chatterjee GC: Biochemical studies on molybdenum toxicity in rats: effects of high protein feeding. Internat. J. Vit. Nutr. Res. 1981, 51, 401-409.
3. Black H, Hutton JB, Sutherland RJ, James MP: White liver disease in goats. N.Z. Vet. J. 1988, 36, 15-17.
4. Bompart G, Pecher C, Precot D, Girolami J-P: Mild renal failure induced by subchronic exposure to molybdenum: urinary kallikrein excretion as a marker of distal tubular effect. Tox. Lett. 1990, 52, 293-300.
5. Brown RO, Forloines-Lynn S, Cross RN, Heizer WD: Chromium deficiency after long-term total parenteral nutrition. Dig. Dis. Sci. 1986, 31, 661-664.
6. Coulson WF, Carnes WH: Cardiovascular studies on copper-deficient swine. V. The histogenesis of the coronary artery lesions. Am. J. Pathol. 1963, 43, 945-954.
7. Davis GK, Mertz W: Copper. In: Mertz W, (ed): Trace elements in human and animal nutrition, vol I. San Diego, New York, Berkeley, Boston, London, Sydney, Tokyo, Toronto: Academic Press, 1987, pp. 301-364.
8. Dollahite JW, Rowe LD, Cook LM, Hightower D, Mailey EM, Kyzar JR: Copper deficiency and molybdenosis intoxication associated with grazing near a uranium mine. Southw. Vet. 1972, 26, 47-50.
9. Dubick GS, Yu M, Majumdar APN: Morphological and biochemical changes in the pancreas of the copper-deficient female rat. J. Nutr. 1989, 119, 1165-1172.
10. Fell BF: The pathology of copper deficiency of animals. In: Howell JMcC, Gawthorne JM (eds): Copper in animals and man. Boca Raton, CRC Press, 1987, vol. 2, pp. 1-28.
11. Fell BF, Dinsdale D, El-Gallad TT: Gut pathology of rats dosed with tetrathiomolybdate. J. Comp. Pathol. 1979, 89, 495-513.
12. Fell BF, Dinsdale D, Mills CF: Changes in enterocyte mitochondria associated with deficiency of copper in cattle. Res. Vet. Sci. 1975, 18, 274-281.
13. Fell BF, Farmer LJ, Farquharson C, Bremner I, Graca DS: Observations on the pancreas of cattle deficient in copper. J. Comp. Pathol. 1985, 95, 573-590.
14. Fell BF, Farquharson C, Riddoch GI: Kidney lesions in copper-deficient rats. J. Comp. Pathol. 1987, 97, 186-196.
15. Fell BF, King TP, Davies NT: Pancreatic atrophy in copper-deficient rats: histochemical and ultrastructural evidence of a selective effect on acinar cells. Histochem. J. 1982, 14, 665-680.
16. Fields M, Lewis CG: Impaired endocrine and exocrine pancreatic functions in copper-deficient rats: the effect of gender. J. Am. Coll. Nutr. 1997, 16, 346-351.
17. Frank A: "Mysterious" moose disease in Sweden. Similarities to copper deficiency and/or molybdenosis in cattle and sheep. Biochemical background of clinical signs and organ lesions. Sci. Total Environ. 1998, 209, 17-26.
18. Frank A, Anke M, Danielsson R: Experimental copper and chromium deficiency and additional molybdenum supplementation in goats. I. Feed consumption and weight development. Sci. Total Environ. 2000a, 249, 133-142.
19. Frank A, Danielsson R, Jones B: Experimental copper and chromium deficiency and additional molybdenum supplementation in goats. II. Concentrations of trace and minor elements in liver, kidneys and ribs: haematology and clinical chemistry. Sci. Total Environ. 2000b, 249, 143-170.
20. Frank A, Galgan V, Petersson LR: Secondary copper deficiency, chromium deficiency and trace element imbalance in the moose (Alces alces L.) Effect of anthropogenic activity. Ambio, 1994, 23, 315-317.
21. Gooneratne SR, Buckley WT, Christensen DA: Review of copper deficiency and metabolism in ruminants. Can. J. Anim. Sci. 1989, 69, 819-845.
22. Hainline BE, Rajagopalan KV: Molybdenum in animal and human health. in: Trace elements in health, a review of current sites, ed. Rose J, London Butterworth. 1983. pp. 150-166.
23. Harris ED: The iron - copper connection: The link to ceruloplasmin grows stronger. Nutr. Rev. 1995, 53, 170-173.
24. Hill CH, Starcher B, Kim C: Role of copper in the formation of elastin. Fed. Proc. 1967, 26, 129-133.
25. Howell JM, Shunxiang Y, Gawthorne JM: Effect of thiomolybdate and ammonium molybdate in pregnant guinea pigs and their offspring. Res. Vet. Sci. 1993, 55, 224-230.
26. Ide H, Yelandi AV, Reddy JK, Rao MS: Increased expression of sulfated glycoprotein-2 and DNA fragmentation in the pancreas of copper-deficient rats. Toxicol. Appl. Pharm. 1994, 126, 174-177.
27. Irwin MR, Poulos PW, Smith BP, Fisher GL: Radiology and histopathology of lameness in young cattle with secondary copper deficiency. J. Comp. Pathol. 1974, 84, 611-621.
28. Ishida N, Kawashima R: Histochemical studies of the skin and wool in sheep reared on high molybdenum diet. Jap. J. Zootech. Sci. 1974, 45, 352-360.
29. Kay R.G: Zinc and copper in human nutrition. J. Hum. Nutr. 1981, 35, 25-36.
30. Merza M, Larsson E, Stéen M, Morein B: Association of a retrovirus with a wasting condition in the Swedish moose. Virology. 1994, 202, 956-961.
31. Mills CF, Davis GK: Molybdenum. In: Mertz W (ed). Trace elements in human and animal nutrition, vol I. San Diego, New York, Berkeley, Boston, London, Sydney, Tokyo, Toronto: Academic Press, 1987, pp. 429-457.
32. Pletcher JM, Banting LF: Copper deficiency in piglets characterized by spongy myelopathy and degenerative lesions in the great blood vessels. J. South Afr. Vet. Assoc. 1983, 3, 43-46.
33. Rana SVS, Kumar A, Bhardwaj NG, Kumar A: Lipids in the liver and kidney of rats, fed various heavy metals. Acta Anat. 1980, 108, 402-412.
34. Rehbinder C, Gimeno E, Belák K, Belák S, Stéen M, Rivera E, Nikkilä T: A bovine viral diarrhoea/mucosal disease-like syndrom in moose (Alces alces L.): investigations on the central nervous system. Vet. Rec. 1991, 129, 552-554.
35. Romeis B: Mikroskopische Technik. (Microscopic technique) Ed.: P. Böck; Urban und Schwarzenberg, München, Wien, 1987.
36. Scott DW: Endocrine diseases, in: Large animal Dermatology, W.B. Saunders Company, 1988, 374-387.
37. Sharma AK, Parihar NS: Pathology of experimental molybdenosis in goats. Ind. J. Anim. Sci. 1994 a, 64, 114-119.
38. Sharma AK, Parihar NS: Clinicopathology of induced molybdenum toxicity in young goats. Ind. J. Anim. Sci. 1994 b, 64, 120-125.
39. Simpson CF, Boucek RJ, Noble NL: Similarity of aortic pathology in Marfan's syndrome, copper deficiency in chicks and B-Aminopropionitrile toxicity in turkeys. Exp. Mol. Path. 1980, 32, 81-90.
40. Stadler R: Elektronenmikroskopische Untersuchung der elastischen Fasern der Haut in Abhängigkeit vom Alter. (Electronmicroscopic studies of elastic fibers of the skin related to the age). Köln, Univ, Fachber. Medizin, Diss. 1978.
41. Stéen M, Diaz R, Faber WE: An erosive/ulcerative alimentary disease of undetermined etiology in Swedish moose (Alces alces L.). Rangifer 1993, 13, 149-156.
42. Sun SH-H, O'Dell BL: Elevated striated levels of glial fibrillary acidic protein associated with neuropathology in copper-deficient rats. J. Nutr. Biochem. 1992, 3, 503-509.
43. Suttle N.F: The role of comparative pathology in the study of copper and cobalt deficiencies in ruminants. J. Comp. Pathol. 1988, 99, 241-258.
44. Suttle NF: Trace element disorders. In: Andrews AH, Blowey RW, Boyed H, Eddy RG (eds): Bovine Medicine, Diseases and husbandry of cattle. London: Blackwell Scientific Publ. 1992, pp. 263-265.
45. Suttle NF, Angus KW: Experimental copper deficiency in the calf. J. Comp. Pathol. 1976, 86, 595-608.
46. Suttle NF, Field AC, Barlow RM: Experimental copper deficiency in sheep. J. Comp. Pathol. 1970, 80, 151-162.
47. Van Niekerk FE, Van Niekerk CH: The influence of experimentally induced copper deficiency on the fertility of rams. I. Semen parameters and peripheral plasma androgen concentration. J. South Afr. Vet. Assoc. 1989 a, 60, 28-31.
48. Van Niekerk FE, Van Niekerk CH: The influence of experimentally induced copper deficiency on the fertility of rams. II. Macro- and Microscopic changes in the testes J. South Afr. Vet. Assoc. 1989 b, 60, 32-35.
49. Waisman J: The ultrastructure and histochemistry of the myocardium in copper-deficient pigs. Fed. proc., 1972, 31, 627.
50. Waisman J, Carnes WH: Cardiovascular studies on copper-deficient swine. Am. J. Pathol. 1967, 51, 117-135.
51. Waisman J, Carnes WH, Weissman N: Some properties of the microfibrils of vascular elastic membranes in normal and copper-deficient swine. Am. J. Pathol. 1969, 54, 107-119.
52. Wallach S: Clinical and biochemical aspects of chromium deficiency. J. Am. College Nutr. 1985, 4, 107-120.
53. Ward GM: Molybdenum toxicity and hypocuprosis in ruminants: a review. J. Anim. Sci. 1978, 46, 1078-1085.