Interaction of bothrojaracin with prothrombin

Haemostasis

Volumn 31, Issue 3-6, 2001, Pages 273-278

  Zingali, Russolina B ^a   Bianconi, M Lucia ^a   Monteiro, Robson Q ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Bothrojaracin; Factor Va; Proexosite I; Prothrombin; Prothrombinase

Indexed keywords

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; BOTHROJARACIN; PHOSPHOLIPID; PROTHROMBIN; THROMBIN; ANTICOAGULANT AGENT; SNAKE VENOM;

ANTICOAGULATION; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; ANIMAL; BINDING SITE; DRUG ANTAGONISM; DRUG INTERACTION; HUMAN; METABOLISM; REVIEW;

ANIMALS; ANTICOAGULANTS; BINDING SITES; CROTALID VENOMS; DRUG INTERACTIONS; HUMANS; PROTHROMBIN; THROMBIN;

EID: 0035743555     PISSN: 03010147     EISSN: None     Source Type: Journal    
DOI: 10.1159/000048073     Document Type: Article

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4. Activation-induced exposure of the thrombin anion-binding exosite
5. A player of many parts: The spotlight falls on thrombin's structure
6. Thrombin specificity
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11. Contribution of the prothrombin fragment 2 domain to the function of factor Va in the prothrombinase complex
12. Role of proexosite I in factor Va-dependent substrate interactions of prothrombin activation
13. Bothrojaracin, a new thrombin inhibitor isolated from Bothrops jararaca venom: Characterization and mechanism of thrombin inhibition
14. Bothrojaracin: A potent two-site-directed thrombin inhibitor
15. Inhibition of thrombin-catalyzed factor V activation by bothrojaracin
16. Allosteric changes of thrombin catalytic site induced by interaction of bothrojaracin with anion-binding exosites I and II
17. Characterization of bothrojaracin interaction with human prothrombin
18. Structural and functional properties of snake venom prothrombin activators
19. Prothrombin activation by an activator from the venom of Oxyuranus scutellatus (Taipan snake)
20. Inhibition of prothrombin activation by bothrojaracin, a C-type lectin from Bothrops jararaca venom