Protein C activators from snake venoms and their diagnostic use

Haemostasis

Volumn 31, Issue 3-6, 2001, Pages 266-272

  Gempeler Messina, Patrizia M ^a   Volz, K ^a   Buhler B ^a   Muller C ^a  

^a Pentapharm Ltd   (Switzerland)

Author keywords

Diagnostic tools; Protein C activators; Snake venom enzymes

Indexed keywords

DIAGNOSTIC AGENT; ENZYME ACTIVATOR; PROTAC; PROTEIN C ACTIVATOR; SNAKE VENOM; UNCLASSIFIED DRUG; ANTICOAGULANT AGENT; PROTEIN C;

ARTICLE; ASSAY; NONHUMAN; PRIORITY JOURNAL; PROTEIN C DEFICIENCY; SCREENING; THROMBOSIS; AGKISTRODON; ANIMAL; BLOOD CLOTTING DISORDER; BLOOD CLOTTING TEST; HUMAN; METABOLISM; REVIEW; THROMBOPHILIA;

AGKISTRODON; ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION DISORDERS; BLOOD COAGULATION TESTS; HUMANS; PROTEIN C; SNAKE VENOMS; THROMBOPHILIA;

EID: 0035742909     PISSN: 03010147     EISSN: None     Source Type: Journal    
DOI: 10.1159/000048072     Document Type: Article

References (42)

1. The protein C anticoagulant pathway
2. The protein C anticoagulant system: Inherited defects as basis for venous thrombosis
3. Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C
4. Regulation of activated protein C by a new protein. A possible function of bovine protein S
5. Inhibition of protein Ca cofactor function of human and bovine protein S by C4b-binding protein
6. Protein C deficiency: A database of mutations, 1995 update
7. Protein S deficiency: A database of mutations - Summary of the first update
8. Protein S deficiency. A database of mutations
9. Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: Prediction of a cofactor to activated protein C
10. Mutation in blood coagulation factor V associated with resistance to activated protein C
11. Activated protein C resistance. A major risk factor for thrombosis
12. Protein C activators in snake venoms
13. Proteinases activating protein C
14. Protein C activation by an activator purified from the venom of Agkistrodon halys halys
15. Protein C activator from the venom of Agkistrodon blomhoffi ussuriensis retards thrombus formation in the arterio-venous shunt in rats
16. Comparative study of protein C activators from the Agkistrodon snake venoms
17. Identification of protein C activator from nine species of Chinese snake venoms
18. Thrombin-like snake venom enzymes
19. Fast functional protein C assay using Protac®, a novel protein C activator
20. Characterization of the protein C activator Protac® from the venom of the southern copperhead (Agkistrodon contortrix) snake
21. Practical application of the protein C activator Protac® from Agkistrodon contortrix venom
22. Assessment of a complex mixture of interacting proteins in the coagulant-active venom from Agkistrodon contortrix contortrix
23. Evaluation of individual variability in the composition of Agkistrodon contortrix contortrix venom by means of HPLC and two-dimensional PAGE
24. Purification of a protein C activator from the venom of the southern copperhead snake (Agkistrodon contortrix contortrix)
25. Characterization of a protein C activator from Agkistrodon contortrix contortrix venom
26. Isolation of a protein C activator from southern copperhead venom
27. Characterization and some properties of the protein C activator from Agkistrodon contortrix contortrix venom
28. Characterization of a protein C activator from the venom of Agkistrodon contortrix contortrix
29. Inhibition of the protein C activator Protac®, a serine proteinase from the venom of the southern copperhead snake Agkistrodon contortrix contortrix
30. Primary structure of a protein C activator from Agkistrodon contortrix contortrix venom
31. Isolation and characterization of a protein C activator from tropical moccasin venom
32. Antithrombotic effect of protein C activator from snake venom
33. Clinical evaluation of protein C: A comparative review of antigenic and functional assays
34. Rapid amidolytic assay of protein C in whole plasma using an activator from the venom of Agkistrodon contortrix
35. Determination of plasma protein S - The protein cofactor of activated protein C
36. The simultaneous measurement of total and free protein S by ELISA
37. Laboratory diagnosis of inherited protein S deficiency
38. Plasma protein S activity measured using Protac®, a snake venom derived activator of protein C
39. A new functional assay for human protein S activity using activated factor V as substrate
40. Functional activity of protein S determined with use of protein C activated by venom activator
41. A prothrombin time-based functional assay of protein S
42. ProC Global: The first functional screening assay for the complete protein C pathway