Enhanced thrombolysis induced by argatroban or activated protein C in the presence or absence of staphylokinase, measured in an in vivo animal model using mesenteric arterioles

Haemostasis

Volumn 31, Issue 2, 2001, Pages 80-89

  Hashimoto, Masaru ^a   Watanabe, Sadahiro ^b   Oiwa, Kazuhiro ^c   Ohta, Yoshio ^d   Kishi, Takeo ^a   Okamoto, Tadashi ^a   Giddings, John C ^e   Yamamoto, Junichiro ^a  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b KOBE CITY COLLEGE OF NURSING   (Japan)

^c NATIONAL INSTITUTE OF INFORMATION AND COMMUNICATIONS TECHNOLOGY   (Japan)

^d KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Activated protein C; Endogenous thrombolysis; Thrombin inhibitors

Indexed keywords

ARGATROBAN; PROTEIN KINASE C; RECOMBINANT ENZYME; STAPHYLOKINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIOLE; ARTERY; ARTICLE; BLOOD CLOT LYSIS; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; IN VIVO STUDY; IRRADIATION; LASER; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT; THROMBOSIS; VEIN; VENULE;

EID: 0035742013     PISSN: 03010147     EISSN: None     Source Type: Journal    
DOI: 10.1159/000048048     Document Type: Article

References (28)

1. Thrombolytic therapy with tissue plasminogen activator or streptokinase induces transient thrombin activity
2. Monitoring of fibrin generation during thrombolytic therapy of acute myocardial infarction with recombinant tissuetype plasminogen activator
3. Safety report from the thrombolysis and thrombin inhibition in myocardial infarction (TIMI) 9A trial
4. A comparison of recombinant hirudin with heparin for the treatment of acute coronary syndromes
5. Adjuvant effect of argatroban on staphylokinase induced thrombolysis of platelet rich thrombi in rat mesenteric venules in vivo
6. Adjuvant effect of antibodies against von Willebrand factor, fibrinogen, and fibronectin on staphylokinase-induced thrombolysis as measured using mural thrombi formed in rat mesenteric venules
7. The differential effects of aspirin on platelets, leukocytes and vascular endothelium in an in vivo model of thrombus formation
8. Evans blue: An ideal energy-absorbing material to produce intravascular microinjury by He-Ne gas laser
9. Effect of physical training on thrombotic tendency in rats: Decrease in thrombotic tendency measured by the He-Ne laser-induced thrombus formation method
10. The differential involvement of von Willebrand factor, fibrinogen and fibronectin in acute experimental thrombosis in rat cerebral and mesenteric microvessels
11. Injury of brain microvessels with a helium-neon laser and Evans blue can elicit local platelet aggregation without endothelial denudation
12. Heparin and the thrombin inhibitor argatroban enhance fibrinolysis by infused or bolus-injected saruplase (r-scu-PA) in rabbit femoral artery thrombosis
13. Animal models for arterial thrombolysis and prevention of reocclusion
14. The effect of thrombin inhibitors on tissue plasminogen activator induced thrombolysis in a rat model
15. Dissolution of mural thrombus by specific thrombin inhibition with rhirudin
16. Small animal thrombosis models for the evaluation of thrombolytic agents
17. Evaluation of the combination of a tissue-type plasminogen activator, SUN9216, and a thromboxane A2 receptor antagonist, vapiprost, in a rat middle cerebral artery thrombosis model
18. Mechanism of fibrin-specific fibrinolysis by staphylokinase: Participation of α2-plasmin inhibitor
19. Thrombolytic properties of staphylokinase
20. On the mechanism of fibrin-specific plasminogen activation by staphylokinase
21. Plasminogen-plasmin system IX. Specific binding of tranexamic acid to plasmin
22. The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent
23. The thrombin paradox
24. A study of the mechanism of inhibition of fibrinolysis by activated thrombin-activable fibrinolysis inhibitor
25. Both cellular and soluble forms of thrombomodulin inhibit fibrinolysis by potentiating the activation of thrombin-activable fibrinolysis inhibitor
26. The effect of activated protein C on fibrinolysis in cell-free plasma can be attributed specifically to attenuation of pro-thrombin activation
27. Thrombin-mediated activation of factor XI results in a thrombin-activatable fibrinolysis inhibitor-dependent inhibition of fibrinolysis
28. Generation of activated protein C during thrombolysis