Thapsigargin-induced calcium entry and apoptotic death of neutrophils are blocked by activation of protein kinase C

Pharmacology

Volumn 63, Issue 3, 2001, Pages 191-196

  Lucas, Miguel ^a   Díaz, Pilar ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN MACARENA   (Spain)

Author keywords

Apoptosis; Endonuclease; Free calcium; Free radicals; Phorbol myristate acetate

Indexed keywords

CALCIUM ION; DNA; ENDONUCLEASE; MEMBRANE PROTEIN; OXYGEN RADICAL; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; THAPSIGARGIN;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL ACTIVATION; CELL MEMBRANE; CONTROLLED STUDY; DNA STRAND BREAKAGE; DRUG EFFECT; DRUG HALF LIFE; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ADENOSINE TRIPHOSPHATASES; APOPTOSIS; CALCIUM; CELL MEMBRANE; DNA; ENDONUCLEASES; ENZYME ACTIVATION; HUMANS; MEMBRANE PROTEINS; NADPH OXIDASE; NEUTROPHIL ACTIVATION; NEUTROPHILS; PHOSPHORYLATION; PROTEIN KINASE C; TETRADECANOYLPHORBOL ACETATE; THAPSIGARGIN; TIME FACTORS;

EID: 0035741977     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000056132     Document Type: Article

References (21)

1. Surface-reactive stimuli selectively increase protein phosphorylation in human neutrophils
2. A time-course study on superoxide generation and protein kinase C activation in human neutrophils
3. 2 production in human neutrophils
4. 2-halide system activity following the respiratory burst of human neutrophils
5. Involvement of protein kinase C in cell survival and apoptotic cell death
6. Induction of programmed cell death (apoptosis) in mature lymphocytes
7. Decreased protein kinase C activity is associated with programmed cell death (apoptosis) in freshly isolated rat hepatocytes
8. 2+ is not required for glucocorticoid-induced apoptosis in thymocytes
9. 2+ requirements and sensitivity to cyclosporine A
10. Phorbol ester induces apoptosis in HL-60 promyelocytic leukemia cells but not in HL-60 PET mutant
11. Activation-induced apoptosis in human macrophages. Developmental regulation of a novel cell death pathway by macrophage colony-stimulating facor and interferon gamma
12. Type I cAMP-dependent protein kinase delays apoptosis in human neutrophils at a site upstream of caspase-3
13. N-acetylsphingosine (C2-ceramide) inhibited neutrophil superoxide formation and calcium influx
14. Chromatin substructure: The digestion of chromatin DNA at regulatory spaced sites by a nuclear deoxyribonuclease
15. Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis
16. Cellular signaling in programmed cell death (apoptosis)
17. Similar actions of glucocorticoids and calcium on the regulation of apoptosis in S49 cells
18. Oxidative stress as a mediator of apoptosis
19. The role of calcium, pH, and cell proliferation in the programmed (apoptotic) death of androgen-independent prostatic cancer cells induced by thapsigargin
20. Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps
21. 2+ stores