Adaptive designs for clinical trials with highly successful treatments

Drug Information Journal

Volumn 35, Issue 4, 2001, Pages 1087-1093

  Ivanova, Anastasia ^a   Rosenberger, William F ^a  

^a IL   (United States)

Author keywords

Ethics; Measures of association; Optimal allocation; Power; Urn models

Indexed keywords

ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; MAXIMUM LIKELIHOOD METHOD; METHODOLOGY; PERFORMANCE; PRIORITY JOURNAL; RANDOMIZATION; RISK; STATISTICAL MODEL; TREATMENT FAILURE;

EID: 0035739854     PISSN: 00928615     EISSN: None     Source Type: Journal    
DOI: 10.1177/009286150103500406     Document Type: Article

References (11)

1. Variability in adaptive designs for estimation of success probabilities
2. A comparison of urn designs for randomized clinical trials of K > 2 treatments
3. Optimal adaptive designs for binary response trials
4. Randomized double-blind study comparing saruplase with streptokinase in acute myocardial infarction: The COMPASS equivalence trial
5. Reduction of maternal-infant transmission of human immuno-deficiency virus type 1 with zidovudine treatment
6. Adaptive survival trials
7. Randomized play-the-winner clinical trials: Review and recommendations
8. The randomized play-the-winner rule in medical trials
9. A birth and death urn for randomized clinical trials: Asymptotic results