Inducible nitric oxide synthase (iNOS) immunoreactivity and its relationship to cell proliferation, apoptosis, angiogenesis, clinicopathologic characteristics, and patient survival in pancreatic cancer

International Journal of Pancreatology

Volumn 29, Issue 3, 2001, Pages 133-140

  Kong, Gu ^a   Kim, Eun Kyung ^b   Kim, Wan Sup ^b   Lee, Yong Wook ^c   Lee, Jong Kyun ^c   Paik, Seung Woon ^c   Rhee, Jong Chul ^c   Choi, Kyoo Wan ^c   Lee, Kyu Taek ^c  

^a Hanyang University   (South Korea)

^b Eulji University School of Medicine   (South Korea)

^c Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Angiogenesis; Apoptosis; Inducible nitric oxide synthase; Pancreatic cancer; Proliferation; Survival

Indexed keywords

KI 67 ANTIGEN; NITRIC OXIDE SYNTHASE;

ADULT; AGED; ANGIOGENESIS; APOPTOSIS; ARTICLE; CANCER RISK; CANCER SURVIVAL; CELL DEATH; CELL PROLIFERATION; ENZYME INDUCTION; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOCARCINOMA; ADOLESCENT; ADULT; AGED; ANTIGENS, CD34; APOPTOSIS; CELL DIVISION; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; KI-67 ANTIGEN; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PANCREATIC NEOPLASMS; SURVIVAL ANALYSIS;

EID: 0035739313     PISSN: 01694197     EISSN: None     Source Type: Journal    
DOI: 10.1385/IJGC:29:3:133     Document Type: Article

References (23)

1. Pancreatic carcinoma
2. Pancreas Club Meeting May 11, 1997 Bethesda, Maryland
3. The L-arginine-nitric oxide pathway
4. Nitric oxide synthases in mammals
5. Role of nitric oxide in cell-mediated tumor cytotoxicity
6. Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or-independent mechanisms
7. Nitric oxide synthase activity in human breast cancer
8. Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53
9. Selective expression of inducible nitric oxide synthase in human prostate carcinoma
10. Nitric oxide synthase activity in human gynecological cancer
11. Frequent nitric oxide synthase-2 expression in human colon adenomas: Implication for tumor angiogenesis and colon cancer progression
12. Role of nitric oxide in tumor progression: Lessons from human tumors
13. Tumor cell nitric oxide inhibits cell growth in vitro, but stimulates tumorigenesis and experimental lung metastasis in vivo
14. Nitric oxide synthase inhibition by N(G)-nitro-L-arginine methyl ester inhibits tumor-induced angiogenesis in mammary tumors
15. Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells
16. Mechanisms for nitric oxide-induced cell death: Involvement of apoptosis
17. Roles of nitric oxide in tumor growth
18. Role of nitric oxide in pancreatic tumour growth: In vivo and in vitro studies
19. Nitric oxide-induced apoptosis in human pancreatic carcinoma cell lines is associated with a G1-arrest and an increase of the cyclin-dependent kinase inhibitor p21WAF1/CIP1
20. Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53
21. Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways
22. Nitric oxide-mediated apoptosis of K-1735 melanoma cells is associated with downregulation of Bcl-2
23. Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis