Segregation of effector mechanisms in a tumour-specific CD8 T-cell clone correlates with CD30 expression

Scandinavian Journal of Immunology

Volumn 54, Issue 3, 2001, Pages 314-320

  Sun, Y ^a   Song, M ^a   Maeurer, M J ^b   Schadendorf, D ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; ANTIGEN; BETA1 INTEGRIN; CD2 ANTIGEN; CD3 ANTIGEN; CD30 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 5; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; LYMPHOTOXIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CASE REPORT; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; HUMAN; HUMAN CELL; LYMPHOCYTE CLONE; LYMPHOCYTE PROLIFERATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TH1 CELL; TH2 CELL; TUMOR CELL;

EID: 0035720441     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2001.00971.x     Document Type: Article

References (23)

1. Production of a monoclonal antibody specific for Hodgkin and Sternberg-Reed cells of Hodgkin's disease and a subset of normal lymphoid cells
2. Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease
3. CD30 is a signal-transducing molecule that defines a subset of human activated CD45RO T cells
4. IL-12 activates IFN-γ production through the preferential activation of CD30 T cells
5. CD30 defines a subset of activated human T cells that produce IFN-γ and IL-5 and exhibit enhanced B cell helper activity
6. CD30 expression on human CD8 T cells isolated from peripheral blood lymphocytes of normal donors
7. CD30 expression identifies a functional alloreactive human T-lymphocyte subset
8. Preferential expression of CD30 by human CD4 T cells producing Th2-type cytokines
9. CD30 expression by CD8 T cells producing type 2 helper cytokines. Evidence for large numbers of CD8 CD30 T cell clones in human immunodeficiency virus infection
10. CD30 expression does not discriminate between human Th1- and Th2-type T cells
11. Reciprocal regulation of CD30 expression on CD4 T cells by IL-4 and IFN-γ
12. Opposite role for interleukin-4 and interferon-γ on CD30 and lymphocyte activation gene-3 (LAG-3) expression by activated naive T cells
13. CD30-mediated signaling promotes the development of human helper type 2-like T cells
14. Vaccination with IL-7 gene-modified autologous melanoma cells can enhance the anti-melanoma lytic activity in peripheral blood of patients with a good clinical performance status: A clinical phase I study
15. In vivo selective expansion of a tumor-specific cytotoxic T-cell clone derived from peripheral blood of a melanoma patient after vaccination with IL-7 gene-modified autologous tumor cells
16. Transfection and expression of a gene coding for a human melanoma antigen recognized by autologous cytotoxic T lymphocytes
17. The expanding universe of T-cell subsets: Th1, Th2 and more
18. IL-4 inhibits IL-2 receptor expression and IL-2-dependent proliferation of human T cells
19. Functional effects of CD30 on a large granular lymphoma cell line, YT. Inhibition of cytotoxicity, regulation of CD28 and interleukin-2R, and induction of homotypic aggregation
20. Expression of the costimulatory receptor CD30 is regulated by both CD28 and cytokines
21. Following the fate of individual T cells throughout activation and clonal expansion: Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response
22. Th2-like CD8 T cells showing B cell helper function and reduced cytotoxic activity in human immunodeficiency virus type 1 infection
23. Multiple sub-sets of CD4 and CD8 cytotoxic T-cell clones directed to autologous human melanoma identified by cytokine profiles