Artificial membrane excitability revisited and implications for the gating of voltage-dependent ion channels

General Physiology and Biophysics

Volumn 20, Issue 4, 2001, Pages 361-374

  Duclohier, H ^a   Spach, G ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

Author keywords

Action potentials; Basic polypeptides; Channel forming peptides; Negative resistance; Secondary structures; Voltage gated ion channels

Indexed keywords

ALAMETHICIN; CALCIUM ION; GLUTAMINE; ION CHANNEL; PHOSPHOLIPID; POLYARGININE; POLYPEPTIDE; PROTAMINE; SODIUM CHANNEL BLOCKING AGENT; SOLVENT; SYNTHETIC PEPTIDE; TETRODOTOXIN;

ARTICLE; ARTIFICIAL MEMBRANE; CHANNEL GATING; CIRCULAR DICHROISM; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EXCITABLE MEMBRANE; ION CONDUCTANCE; ION CURRENT; IONIC STRENGTH; LIPID BILAYER; MEMBRANE CONDUCTANCE; MEMBRANE POTENTIAL; PHASE SEPARATION; SURFACE CHARGE;

ACTION POTENTIALS; ALAMETHICIN; AMINO ACID SEQUENCE; ANESTHETICS, LOCAL; CALCIUM; CALCIUM CHLORIDE; CIRCULAR DICHROISM; DRUG RESISTANCE; ELECTROPHYSIOLOGY; ION CHANNELS; LIPID BILAYERS; MEMBRANES, ARTIFICIAL; MOLECULAR SEQUENCE DATA; PEPTIDES; POLYLYSINE; POTASSIUM CHLORIDE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; TETRODOTOXIN;

EID: 0035719927     PISSN: 02315882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. A reinterpretation of Na channel gating and permeation in terms of a phase transition between a transmembrane S4 α-helix and a channel-helix
2. Erregbarkeit Schwarzer Lipid-Membranen. Ein beitrag zur klärung der erregungsvorgänge in dem durch alamethicin und protamin modifizierten membranmodellsystem
3. Statistical analysis of alamethicin channels in black lipid membranes
4. Alamethicin: A peptide model for voltage gating and protein-membrane interactions
5. Interaction of natural and model peptides with membranes
6. Circular dichroic analysis of protein conformation: Inclusion of β-turns
7. C-terminally shortened alamethicin on templates: Influence of the linkers on conductances
8. The nature of the voltage-dependent conductance induced by alamethicin in black lipid membranes
9. Spatio-temporal patterns in the fluid-mosaic model of membranes
10. Potential-dependent conductances in lipid membranes containing alamethicin
11. Alamethicin, a rich model for channel behavior
12. Ion channel reconstitution into planar lipid bilayers on glass pipettes
13. Voltage-sensitivity and conformational change of isolated S4L45 fragments from sodium channels are tuned to proline
14. A quantitative description of membrane current and its application to conduction and excitation in nerve
15. Phase separation in phospholipid bilayers induced by biologically active polycations
16. Oscillatory phenomena in model membranes: Electrical oscillations in lipid-impreganted membrane filter induced by alamethicin and controlled by bacteriorhodopsin
17. Oscillations and spatial nonuniformities in membranes
18. Long-range interactions, voltage sensitivity, and ion conduction in S4 segments of excitable channels
19. Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification
20. Chemical nature and sequence of alamethicin
21. A corrected primary sequence for bull protamine
22. Ca(2+)-induced lateral phase separation in black lipid membranes and its coupling to the ion translocation by gramicidin
23. Formation of bimolecular membranes from lipid monolayers and a study of their properties
24. Induced excitability in reconstituted cell membrane structure
25. Action potentials induced in bimolecular lipid membranes
26. Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence
27. Effects of polycations on ion channels by neutral and negatively-charged alamethicins
28. The biophysics of peptide models of ion channels
29. Voltage gating of ion channels
30. Periodic responses in squid axon membrane exposed intracellularly and extracellularly to solutions containing a single species of salt
31. A possible mechanism for the negative resistance characteristic of axon membranes
32. Interactions of polyamines with ion channels
33. Probing the outer vestibule of a sodium channel voltage sensor