Reduction of 1-methyl-1-nitrosourea-induced mammary gland carcinoma by in vivo application of immunostimulatory CpG motifs in Sprague-Dawley rats

General Physiology and Biophysics

Volumn 20, Issue 4, 2001, Pages 445-448

  Macejova D ^a   Dvorcakova M ^a   Weiss, R ^a   Scheiblhofer, S ^a   Mostbock S ^a   Liska J ^a   Szabova L ^a   Zorad S ^a   Thalhamer, J ^a   Brtko, J ^a  

^a INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

Author keywords

CpG motifs; Immunostimulatory sequences; Mammary gland; Retinoic acid; Sprague Dawley rats; Tumours

Indexed keywords

IMMUNOSTIMULATING AGENT; ISOTRETINOIN; METHYLNITROSOUREA; OLIGODEOXYNUCLEOTIDE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CARCINOMA; BREAST TUMOR; CONTROLLED STUDY; CPG ISLAND; DRUG EFFECT; DRUG POTENTIATION; DRUG RESPONSE; FEMALE; IMMUNE RESPONSE; IMMUNOSTIMULATION; IN VIVO STUDY; NONHUMAN; PROTEIN MOTIF; RAT; RAT STRAIN; TH1 CELL; TUMOR IMMUNITY; TUMOR VOLUME;

ALKYLATING AGENTS; AMINO ACID MOTIFS; ANIMALS; CARCINOGENS; CPG ISLANDS; FEMALE; MAMMARY NEOPLASMS, ANIMAL; METHYLNITROSOUREA; MODELS, STATISTICAL; NEOPLASMS, EXPERIMENTAL; RATS; RATS, SPRAGUE-DAWLEY; TRETINOIN;

ANIMALIA;

EID: 0035719901     PISSN: 02315882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. DNA immunization in vivo down-regulates nuclear all-trans retinoic acid receptors in mouse spleen cells
2. Retinoids and vertebrate development
3. A Toll-like receptor recognizes bacterial DNA
4. CpG motifs in bacterial DNA trigger direct B-cell activation
5. Mammary gland carcinoma-related increase of type I iodothyronine 5′-deiodinase activity in Sprague-Dawley rats
6. Dietary retinoids and carotenoids in rodent models of mammary carcinogenesis
7. Macrophages sense pathogens via DNA motifs: Induction of tumor necrosis factor-alpha-mediated shock
8. Macrophages ingest and are activated by bacterial DNA
9. Type I interferon-mediated stimulation of T cells by CpG DNA