Reduced skeletal muscle calpain-10 transcript level is due to a cumulative decrease in major isoforms

Molecular Genetics and Metabolism

Volumn 73, Issue 1, 2001, Pages 111-113

  Yang, Xiaolin ^a   Pratley, Richard E ^a   Baier, Leslie J ^a   Horikawa, Yukio ^b   Bell, Graeme I ^b   Bogardus, Clifton ^a   Permana, Paska A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Calpain 10; Isoforms; Pima Indians; Skeletal muscle; Type 2 diabetes

Indexed keywords

CALPAIN; CALPAIN 10A; CALPAIN 10F; MESSENGER RNA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENETIC TRANSCRIPTION; HOMOZYGOSITY; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SPLICING; SINGLE NUCLEOTIDE POLYMORPHISM; SKELETAL MUSCLE; SPLICEOSOME;

EID: 0035718894     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1006/mgme.2001.3171     Document Type: Article

References (7)

1. Genetic variation in the calpain-10 gene (CAPN10) is associated with type 2 diabetes mellitus
2. A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance
3. Diabetes incidence and prevalence in Pima Indians: A 19-fold greater incidence than in Rochester, Minnesota
4. Familiality of physical and metabolic characteristics that predict the development of non-insulin dependent diabetes mellitus in Pima Indians
5. Aspects of splice site selection in constitutive and alternative pre-mRNA splicing
6. Expression of MEF2 genes during human cardiac development
7. Insulin resistance is associated with reduced fasting and insulin-stimulated glycogen synthase phosphatase activity in human skeletal muscle