Drug resistance in epithelial ovarian cancer: P-glycoprotein and glutation S-transferase. Can they play an important role in detecting response to platinum-based chemotherapy as a first-line therapy

European Journal of Gynaecological Oncology

Volumn 22, Issue 6, 2001, Pages 436-438

  Simsek T ^a   Ozbilim G ^a   Gulkesen H ^a   Kaya, H ^a   Sargin, F ^a   Karaveli, S ^a  

^a Culfalar apt ^*  (Turkey)

Author keywords

Drug Resistance; Glutation S transferase; Ovarian Cancer; P glycoprotein

Indexed keywords

CISPLATIN; CYCLOPHOSPHAMIDE; GLUTATHIONE TRANSFERASE; GLYCOPROTEIN P;

ADULT; AGED; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN TISSUE; OVARY CANCER; TREATMENT OUTCOME;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CISPLATIN; DRUG RESISTANCE, NEOPLASM; FEMALE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; MIDDLE AGED; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; P-GLYCOPROTEIN;

EID: 0035717955     PISSN: 03922936     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Significance of multidrug-resistant proteins in predicting chemotherapy response and prognosis in epithelial ovarian cancer
2. Mechanisms and modulation of resistance to chemotherapy in ovarian cancer
3. High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutation synthesis
4. Sensitization of drug resistant human ovarian cancer cells to cyanomorpholino doxorubicin (MRA-CN) by modulation of glutathione metabolism
5. Multiple drug resistance parameter expression in ovarian cancer
6. Glutathione concentration may be a useful predictor of response to second-line chemotherapy in patients with ovarian cancer
7. The role of detoxifying systems in resistance of tumor cells to cisplatin and adriamycin
8. Increased expression of cytosolic glutathione S-transferases in drug resistant L5178Y murine lymphoblasts: Chemical selectivity and molecular mechanisms
9. Glutathione S-transferase expression in benign and malignant ovarian tumours
10. Expression of P-glycoprotein in epithelial ovarian cancer: Evaluation as a marker of multidrug resistance
11. Expression of a human multidrug resistance gene in ovarian carcinomas
12. P-glycoprotein expression and DNA topoisomerase I and II activity in benign tumors of the ovary and in malignant tumors of the ovary, before and after platinum/cyclophosphamide chemotherapy