KM+, a lectin from Artocarpus integrifolia, induces IL-12 p40 production by macrophages and switches from type 2 to type 1 cell-mediated immunity against Leishmania major antigens, resulting in BALB/c mice resistance to infection

Glycobiology

Volumn 11, Issue 12, 2001, Pages 1035-1042

  Panunto Castelo, Ademilson ^a   Souza, Maria A ^a,b   Roque Barreira, Maria Cristina ^a   Silva, João S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF UBERLÂNDIA   (Brazil)

Author keywords

Artocarpus integrifolia; Interleukin 12; KM+; Lectin; Leishmania major

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 12; INTERLEUKIN 4; MANNOSE BINDING LECTIN; MANNOSE BINDING PROTEIN; PARASITE ANTIGEN; PROTEIN P40; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FOOT PAD; IMMUNIZATION; IMMUNOSTIMULATION; IN VIVO STUDY; INFECTION RESISTANCE; INFECTION SENSITIVITY; LEISHMANIA MAJOR; LEISHMANIASIS; LYMPH NODE CELL; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; SUPERNATANT; TH1 CELL; TH2 CELL;

ANIMALIA; ARTOCARPUS; ARTOCARPUS HETEROPHYLLUS; LEISHMANIA MAJOR; MURINAE; PROTOZOA;

EID: 0035715299     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/11.12.1035     Document Type: Article

References (28)

1. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major
2. The adjuvant effect of jacalin on the mouse humoral immune response to trinitrophenyl and Trypanosoma cruzi
3. A subunit vaccine candidate region of the Entamoeba histolytica galactose-adherence lectin promotes interleukin-12 gene transcription and protein production in human macrophages
4. +
5. In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease
6. Lectin affinity chromatography of proteins bearing O-linked oligosaccharides: Application of jacalin agarose
7. A plant lectin derived from Viscum album induces cytokine gene expression and protein production in cultures of human peripheral blood mononuclear cells
8. Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system
9. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
10. Priming by microbial antigens from the intestinal flora determines the ability of CD4(+) T cells to rapidly secrete IL-4 in BALB/c mice infected with Leishmania major
11. Resistance to Leishmania major induced by tolerance to a single antigen
12. Lectin of Bacillus subtilis sp. as overinducer of gamma-interferonogenesis
13. IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice
14. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4- producing cells
15. Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells
16. Carbohydrate-bearing cell surface receptors involved in innate immunity: Interleukin-12 induction by mitogenic and nonmitogenic lectins
17. Lymphocyte responses and cytokines
18. The role of monocytes in the induction and regulation of IFN-gamma production by lectin-activated human T lymphocytes
19. Thermodynamic studies of saccharide binding to artocarpin, a B-cell mitogen, reveals the extended nature of its interaction with mannotriose [3, 6-Di-O-(alpha-D-mannopyranosyl)-D-mannose]
20. The regulation of immunity to Leishmania major
21. +, a mannose-specific lectin from Artocarpus integrifolia: Amino acid sequence, predicted tertiary structure, carbohydrate recognition and analysis of the beta-prism fold
22. A neutrophil migration-inducing lectin from Artocarpus integrifolia
23. Vaccination against cutaneous leishmaniasis in a murine model. I. Induction of protective immunity with a soluble extract of promastigotes
24. Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming
25. The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice
26. Resolution of cutaneous leishmaniasis: Interleukin 12 initiates a protective T helper type 1 immune response
27. Involvement of CD4 in interleukin-6 secretion by U937 monocytic cells stimulated with the lectin jacalin
28. Signaling pathways for transduction of the initial message of the glycocode into cellular responses