Tissue concentrations and induction of a hepatic monooxygenase in male Wistar rats after repeated doses of defined polychlorinated dibenzo-p-dioxin and dibenzofuran (PCDDs and PCDFs) mixtures

Archives of Toxicology

Volumn 75, Issue 11, 2002, Pages 653-664

  Körner, Wolfgang ^a,c   Golor, Georg ^b   Schulz, Thomas ^b   Wiesmüller, Thomas ^a   Hagenmaier, Hanspaul ^a   Neubert, Diether ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c Bayerisches Landesamt für Umweltschutz   (Germany)

Author keywords

Ethoxyresorufin O deethylase; Kinetics; Polychlorinated dibenzo p dioxins; Polychlorinated dibenzofurans; Tissue distribution; Toxicity equivalency factors

Indexed keywords

1,2,3,6,7,8 HEXACHLORODIBENZO 4 DIOXIN; 1,2,3,7,8 PENTACHLORODIBENZOFURAN; 2,3,4,7,8 PENTACHLORODIBENZOFURAN; 2,3,7,8 HEPTACHLORODIBENZOFURAN; 2,3,7,8 HEXACHLORODIBENZOFURAN; 2,3,7,8 OCTACHLORODIBENZOFURAN; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 2,3,7,8 TETRACHLORODIBENZOFURAN; DIBENZOFURAN DERIVATIVE; DIOXIN; ETHOXYRESORUFIN DEETHYLASE; POLYCHLORINATED DIBENZODIOXIN; POLYCHLORINATED DIBENZOFURAN; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ADIPOSE TISSUE; ANIMAL TISSUE; ARTICLE; CHLORINATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; ENZYME ACTIVITY; ENZYME INDUCTION; ISOMER; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE DISTRIBUTION;

ANIMALIA; ILEX COOKII; RATTUS NORVEGICUS;

EID: 0035714273     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040100276     Document Type: Article

References (26)

1. Pharmacokinetics and biological activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. 1. Dose-dependent tissue distribution and induction of hepatic ethoxyresorufin O-deethylase in rats following a single injection
2. Absorption and tissue distribution of various polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) in the rat
3. Studies on the retention of individual polychlorinated dibenzofurans (PCDFs) in the liver of different species
4. Separation of polychlorodibenzo-p-dioxins and -dibenzofurans on the new polar stationary phase DB DIOXIN
5. Disposition of octachlorodibenzodioxin (OCDD) in male rats
6. Subchronic effects of exposure to octachlorodibenzodioxin (OCDD)
7. Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: A series of substrates to distinguish between different induced cytochromes P-450
8. Dioxin-like effects observed in male rats following exposure to octachlorodibenzodioxin (OCDD) during a 13-week toxicity study
9. Biological activity and tissue concentrations of TCDD and OCDD in rats after s.c. application alone and in combination
10. Concentration effect analyses with TCDD, H7CDD and OCDD in female Wistar rats
11. Selective determination of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the presence of a large excess of the polychlorinated dibenzodioxins and polychlorinated dibenzofurans
12. Copper-catalyzed dechlorination/hydrogenation of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and other chlorinated aromatic compounds
13. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) effects on hepatic microsomal cytochrome P-448-mediated enzyme activities
14. Pilot study on international information exchange on dioxins and related compounds. International equivalency factors (I-TEF) method of risk assessment for complex mixtures of dioxins and related compounds
15. Persistence of various polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) in hepatic and adipose tissue of marmoset monkeys
16. TCDD toxicity equivalencies for PCDD/PCDF congeners: Prerequisites and limitations
17. Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a potent inducer of aryl hydrocarbon hydroxylase, with 3-methylcholanthrene
18. Comparison of the induction of cytochrome P450 and ethoxyresorufin O-deethylase by a single subcutaneous administration of TCDD in liver microsomes of marmoset monkeys (Callithrix jacchus) and rats
19. Inductive potency of TCDD, TBDD and three 2,3,7,8-mixed-halogenated dioxins in liver microsomes of male rats. Enzyme kinetic considerations
20. Selective retention of PCDDs and PCDFs in mammals: A multiple cause problem
21. Retention of PCDDs and PCDFs in the liver of the rat and hamster after oral administration of a municipial incinerator fly ash extract
22. The toxicokineties and metabolism of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) and their relevance for toxicity
23. Toxic equivalency factors (TEFs) for PCBs, PCDDs, PCDFs for humans and wildlife
24. Metabolic degradation, inducing potency, and metabolites of fluorinated and chlorinated-fluorinated dibenzodioxins and dibenzofurans
25. Results of a 9-month feeding study with OCDD and OCDF in rats