Possible mechanism of toxicity of zidovudine by induction of apoptosis of CD4+ and CD8+ T-cells in vivo

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 20, Issue 12, 2001, Pages 896-897

  Benveniste, O ^a,c   Estaquier, J ^b   Lelievre J ^b   Vilde J ^a   Ameisen, J ^b   Leport, C ^a  

^a BICHAT HOSPITAL   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INDINAVIR; LAMIVUDINE; NELFINAVIR; STAVUDINE; ZIDOVUDINE;

APOPTOSIS; ARTICLE; BLOOD TOXICITY; CASE REPORT; CLINICAL FEATURE; DISEASE COURSE; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG WITHDRAWAL; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; PRIORITY JOURNAL; T LYMPHOCYTE; TREATMENT OUTCOME; VIRUS LOAD;

ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; HIV INFECTIONS; HUMANS; ZIDOVUDINE;

EID: 0035710888     PISSN: 09349723     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10096-001-0635-7     Document Type: Article

References (6)

1. Clinical outcome of patients with HIV-1 infection according to immunologic and virologic response after 6 months of highly active antiretroviral therapy
2. In vivo toxicity of 3′ -azido-3′ -deoxythymidine (AZT) on CBA/Ca mice
3. Effects of zidovudine in 365 consecutive patients with AIDS or AIDS-related complex
4. Peripheral blood and bone marrow findings in patients with acquired immune deficiency syndrome
5. Early changes in peripheral blood T cells during primary infection of rhesus macaques with pathogenic SIV
6. Reduction in T cell apoptosis in patients with HIV disease following antiretroviral therapy