Evaluation of gum karaya as a carrier in the design of oral controlled-release hydrophilic matrix systems

Acta Pharmaceutica

Volumn 51, Issue 4, 2001, Pages 273-287

  Murali Mohan Babu, G V ^a   Prasad, C D S ^a   Hima Sankar, K ^a   Narayan, Cheruvu P S ^a   Ramana Murthy, K V ^a  

^a ANDHRA UNIVERSITY   (India)

Author keywords

Diclofenac sodium; Flurbiprofen; Gum karaya; Hydrophilic matrix; Theophylline

Indexed keywords

BN 94062; DICLOFENAC; FLURBIPROFEN; KARAYA GUM; THEOPHYLLINE;

ARTICLE; CONTROLLED RELEASE FORMULATION; DISSOLUTION; DRUG DESIGN; DRUG FORMULATION; DRUG SOLUBILITY; HUMAN; HYDROPHILICITY; NORMAL HUMAN; PH;

EID: 0035707324     PISSN: 13300075     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Swelling controlled-release systems: Recent developments and applications
2. Zero-order release hydrophilic matrix tablets of β-adrenergic blockers
3. Evaluation of hydrogel based controlled-release Niacin tablets
4. In vitro and in vivo evaluation of a xanthan gum-n-octenylsuccinate starch matrix tablet containing ibuprofen as a model drug
5. Gum karaya
6. Release characteristics of diclofenac sodium from encapsulated natural gum mini-matrix formulations
7. A rapid and sensitive HPLC method for determination of diclofenac sodium in serum and its use in pharmacokinetic studies
8. Analytical method validation: Bioavailability, bioequivalence and pharmacokinetic studies
9. Kinetic analysis of blood levels and urinary excretion in the absorption phase after single doses of drug
10. Moment analysis in vivo and in vitro
11. Evaluation of xanthan gum as a hydrophilic matrix for controlled-release dosage form preparations
12. Gums
13. The kinetics of drug release from ethyl cellulose solid dispersions
14. Investigation of factors influencing release of solid drug dispersed in wax matrices III. Quantitative studies involving polyethylene plastic matrix
15. Mechanism of sustained action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
16. Kinetics of in vitro release of sodium salicylate dispersed in Gelucire
17. Mechanism of solute release from porous hydrophilic polymers
18. A simple equation for description of solute release. I. Fickian and non-fickian release from non-swellable devices in the form of, slabs, spheres cylinders or disks
19. A simple equation for description of solute rel. II Fickian and anomalous release from swellable devices
20. Moment analysis in vivo and in vitro
21. Specifications for identity and purity
22. Studies on drug release from a carbomer tablet matrix
23. Effects of excipients on swelling and drug release from compressed matrices
24. Studies of gum karaya mucilages
25. Studies on drug release kinetics from ibuprofen-corbomer hydrophilic matrix tablet: Influence of co-excipients on release rate of the drug
26. Utilization of hydrophilic gums for the control of drug release from tablet formulations. I. Disintegration and dissolution behaviour
27. Release mechanisms in gel forming sustained-release preparations
28. Swelling and drug release behaviour of xanthan gum matrix tablets
29. Dissolution of diclofenac sodium from matrix tablets
30. Application of the solid dispersion method to the controlled-release of medicine. III. Control of the release rate of slightly water soluble medicine from solid dispersion granules
31. In vivo evaluation of xanthan gum as a potential excipient for oral controlled-release matrix tablet formulation