Enhancement of diphtheria toxin-induced apoptosis in Vero cells by combination treatment with brefeldin A and okadaic acid

Cell Structure and Function

Volumn 26, Issue 5, 2001, Pages 279-288

  Kusano, Izumi ^a   Kageyama, Ai ^a   Tamura, Tadashi ^a   Oda, Tatsuya ^a   Muramatsu, Tsuyoshi ^a  

^a NAGASAKI UNIVERSITY   (Japan)

Author keywords

Apoptosis; Brefeldin A; Diphtheria toxin; Golgi complex; Okadaic acid; Ricin

Indexed keywords

ADENOSINE DIPHOSPHATE; AMMONIUM CHLORIDE; BREFELDIN A; DIPHTHERIA TOXIN; DNA FRAGMENT; ELONGATION FACTOR 2; OKADAIC ACID; REAGENT; RICIN;

ADENOSINE DIPHOSPHATE RIBOSYLATION; APOPTOSIS; ARTICLE; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONCENTRATION (PARAMETERS); CYTOLYSIS; CYTOSOL; ENZYME INACTIVATION; GOLGI COMPLEX; MODULATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; VERO CELL;

4-CHLORO-7-NITROBENZOFURAZAN; AMMONIUM CHLORIDE; ANIMALS; BACTERIAL PROTEINS; BREFELDIN A; CELL NUCLEUS; CERAMIDES; CERCOPITHECUS AETHIOPS; DIPHTHERIA TOXIN; DIURETICS; DNA FRAGMENTATION; DRUG SYNERGISM; ENZYME INHIBITORS; GOLGI APPARATUS; OKADAIC ACID; PROTEIN SYNTHESIS INHIBITORS; RICIN; VERO CELLS;

EID: 0035702625     PISSN: 03867196     EISSN: None     Source Type: Journal    
DOI: 10.1247/csf.26.279     Document Type: Article

References (43)

1. Internucleosomal DNA cleavage precedes diphtheria toxin-induced cytolysis: Evidence that cell lysis is not a simple consequence of translation inhibition
2. Comparison of the intoxication pathways of tumor necrosis factor and diphtheria toxin
3. Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis
4. Diphtheria toxin receptor: Identification of specific diphtheria toxin-binding proteins on the surface of Vero and BS-C-1 cells
5. Golgi-disturbing agents
6. Brefeldin A redistributes resident and itinerant Golgi proteins to the endoplasmic reticulum
7. Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum
8. Receptor-mediated endocytosis: Concepts emerging from the LDL receptor system
9. The toxic plant proteins ricin and abrin induce apoptotic changes in mammalian lymphoid tissues and intestine
10. Okadaic acid treatment leads to a fragmentation of the trans-Golgi network and an increase in expression of TGN38 at the cell surface
11. Ribotoxic stress response: Activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the α-sarcin/ricin loop in the 28S rRNA
12. Macrophage adherence prevents apoptosis induced by ricin
13. Involvement of both caspase-like proteases and serine proteases in apoptotic cell death induced by ricin, modeccin, diphtheria toxin, and Pseudomonas toxin
14. + and ATP levels during ricin-induced apoptosis through the specific ribosomal inactivation results in the cytolysis of U937 cells
15. Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER
16. Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic
17. A vital stain for Golgi apparatus
18. Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis
19. Identification of diphtheria toxin receptor and a nonproteinous diphtheria toxin-binding molecule in Vero cell membrane
20. Bacterial toxins: Cellular mechanisms of action
21. Isolation and characterization of ricin E from castor beans
22. Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes
23. Synergistic effect of tumor necrosis factor-α and diphtheria toxin-mediated cytotoxicity in sensitive and resistant human ovarian tumor cell lines
24. Diphtheria toxin and Pseudomonas A toxin-mediated apoptosis
25. Ricin-mediated cell lysis and apoptosis of drug sensitive and resistant tumor cells
26. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
27. Brefeldin A arrests the intracellular transport of a precursor of complement C3 before its conversion site in rat hepatocytes
28. Cerulenin inhibits the cytotoxicity of ricin, modeccin, Pseudomonas toxin, and diphtheria toxin in brefeldin A-resistant cell lines
29. Protective effect of cell-permeable ceramide analogs against modeccin, ricin, Pseudomonas toxin, and diphtheria toxin
30. Cell lysis induced by ricin D and ricin E in various cell lines
31. Involvement of N-acetylcysteine-sensitive pathways in ricin-induced apoptotic cell death in U937 cells
32. How protein toxins enter and kill cells
33. Protein toxins with intracellular targets
34. Multiple targets for brefeldin A
35. Perturbation of the morphology of the trans-Golgi network following brefeldin A treatment: Redistribution of TGN-specific integral membrane protein, TGN38
36. Rapid entry of nicked diphtheria toxin into cells at low pH. Characterization of the entry process and the effects of low pH on the toxin molecule
37. Entry of the toxin protein abrin, modeccin, ricin and diphtheria toxin into cells. II. Effect of pH, metabolic inhibitors and ionophores and evidence for penetration from endocytic vesicles
38. Evidence that diphtheria toxin and modeccin enter the cytosol from different vesicular compartments
39. Endocytosis from coated pits of Shiga toxin: A glycolipid-binding protein from Shigella dysenteriae 1
40. Toxin-induced cell lysis: Protection by 3-methyladenine and cycloheximide
41. Diphtheria toxin and related proteins. II Kinetic studies on intoxication of HeLa cells by diphtheria toxin and related proteins
42. Increased cytotoxicity of ricin in a putative Golgi-defective mutant of chinese hamster ovary cell
43. Disruption of the Golgi apparatus by brefeldin A inhibits the cytotoxicity of ricin, modeccin, and Pseudomonas toxin