Chiral pharmacokinetics of ketorolac in sheep after intravenous and intramuscular administration of the racemate

Journal of Veterinary Pharmacology and Therapeutics

Volumn 24, Issue 6, 2001, Pages 443-446

  Santos, Y ^a   Ballesteros, C ^a   Ros, J M ^a   Lazaro R ^a   Rodriguez C ^a   Encinas, T ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; KETOROLAC;

ANIMAL EXPERIMENT; ARTICLE; CHIRALITY; CONTROLLED STUDY; DOSE CALCULATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG PROTEIN BINDING; DRUG TRANSFORMATION; DRUG USE; ENANTIOMER; FEMALE; MEAN RESIDENCE TIME; NONHUMAN; PAIN; PRIORITY JOURNAL; RACEMIC MIXTURE; SHEEP; SPECIES DIFFERENCE; TIME;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; BIOTRANSFORMATION; CROSS-OVER STUDIES; FEMALE; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAVENOUS; ISOMERISM; KETOROLAC; SHEEP;

ANIMALIA; OVIS ARIES;

EID: 0035702533     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2885.2001.00370.x     Document Type: Article

References (22)

1. Clinical pharmacokinetics of ketorolac tromethamine
2. The metabolic chiral inversion and dispositional enantioselectivity of the 2-arylpropionic acids and their biological consequences
3. Stereoselective inhibition of inducible cyclooxygenase by chiral nonsteroidal antiinflammatory drugs
4. The kinetics of particulate matter in the rumen
5. Ketorolac: A reappraisal of its pharmacodynamic and pharmacokinetics properties and therapeutic use in pain management
6. Absolute configuration of (-)-5-benzoyl-1,2-dihydro-3H-pyrrrolo[1,2,-a]pyrrole-1-carboxylic acid, the active enantiomer of ketorolac
7. Stereoselective pharmacokinetics of ketorolac in children, adolescents and adults
8. Chirality and nonsteroidal anti-inflammatory drugs
9. The pharmacokinetics of ketorolac enantiomers following intramuscular administration of the racemate
10. Stereospecific pharmacokinetics and toxicodynamics of ketorolac after oral administration of the racemate and optically pure enantiomers to the rat
11. Pharmacokinetics of ketorolac tromethamine in humans after intravenous, intramuscular and oral administration
12. Enantiomer-selective pharmacokinetics and metabolism of ketorolac in children
13. Enantioselective behaviour of drugs used in domestic animals: A review
14. Differencial inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs
15. A comparison of ketorolac with flunixin, butorphanol, and oxymorphone in controlling postoperative pain in dogs
16. 1-acid glycoprotein chiral stationary phase and ultraviolet detection
17. Chiral kinetics and dynamics of ketorolac
18. Pharmacokinetics of (-)S(+)R enantiomers of ketorolac (K) in humans following administration of racemic ketorolac tromethamine (KT)
19. Ketorolac tromethamine pharmacokinetic and metabolism after intravenous, intramuscular and oral administration in humans and animals
20. The pharmacokinetics of postoperative intravenous ketorolac tromethamine in children
21. Pharmacokinetics of ketorolac after intravenous and oral single dose administration in dogs
22. PKCALC: A basic interactive computer program for statistical and pharmacokinetic analysis of data