Accumulation of 125Iodine labeled interleukin-2 in the pancreas of NOD mice

Journal of Autoimmunity

Volumn 17, Issue 4, 2001, Pages 281-287

  Rolandsson, O ^a   Stigbrand, T ^a   Riklundahlstrom K ^a   Eary, J ^b   Greenbaum, C ^c,d  

^a UMEÅ UNIVERSITY   (Sweden)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d BENAROYA RESEARCH INSTITUTE   (United States)

Author keywords

125Iodine; BB W rat; Biodistribution; IL 2; Insulitis; NOD mouse; Scintigraphic methods; Type 1 diabetes

Indexed keywords

INTERLEUKIN 2; IODINE 125;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; FEMALE; IMMUNOPATHOGENESIS; INSULIN DEPENDENT DIABETES MELLITUS; ISOTOPE LABELING; MOUSE; NONHUMAN; PANCREAS; PANCREAS SCINTISCANNING; PRIORITY JOURNAL; RADIOISOTOPE DISTRIBUTION; RAT; TISSUE DISTRIBUTION;

EID: 0035702332     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.2001.0555     Document Type: Article

References (16)

1. Pathologic anatomy of the pancreas in juvenile diabetes mellitus
2. Insulitis in type 1 (insulin-dependent) diabetes mellitus in man - Macrophages, lymphocytes, and interferon-gamma containing cells
3. Autoantibodies to glutamic acid decarboxylase and insulin in islet cell antibody positive presymptomatic type 1 diabetes mellitus: Frequency and segregation by age and gender
4. Heterogeneity of islet pathology in two infants with recent onset diabetes mellitus
5. Examination of islets in the pancreas biopsy specimens from newly diagnosed type 1 (insulin-dependent) diabetic patients
6. Type-I diabetes: A chronic autoimmune disease of human, mouse, and rat
7. Labelling of interleukin-2 (IL-2) with 123-iodine with retention of its capacity to bind to activated lymphocytes
8. A radiopharmaceutical for imaging areas of lymphocytic infiltration: 123I-interleukin-2. Labelling procedure and animal studies
9. New approach for in vivo detection of insulitis in type I diabetes: Activated lymphocyte targeting with 123I-labelled interleukin 2
10. Detection of activated lymphocytes in endocrine pancreas of BB/W rats by injection of 123I-interleukin-2: An early sign of type 1 diabetes
11. Detection of pancreatic insulitis in type-1 diabetes by using 123I-labelled interleukin-2
12. In vivo bio distribution and metabolism of radio labelled IL2 in normal and diabetes prone mice
13. Class-II and IL2 receptor positive cells in the pancreas of NOD mice
14. Sialadenitis in nonobese diabetic mice: Transfer into syngeneic healthy neonates by splenic T lymphocytes
15. Elevated levels of cysteine protease activity in saliva and salivary glands of the nonobese diabetic (NOD) mouse model for Sjogren syndrome
16. The prevention of type I diabetes mellitus