Synthetic peptides as functional mimics of a viral discontinuous antigenic site

Biologicals

Volumn 29, Issue 3-4, 2001, Pages 265-269

  Villén, Judit ^a   Borràs, Eva ^a   Schaaper, Wim M M ^b   Meloen, Rob H ^b   Dávila, Mercedes ^c   Domingo, Esteban ^c   Giralt, Ernest ^a   Andreu, David ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Pepscan Systems   (Netherlands)

^c CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

FOOT AND MOUTH DISEASE VACCINE; MONOCLONAL ANTIBODY; PEPTIDE D8; PROLINE; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN RECOGNITION; ANTIVIRAL ACTIVITY; CONFERENCE PAPER; CONTROLLED STUDY; DISULFIDE BOND; ENZYME LINKED IMMUNOSORBENT ASSAY; FOOT AND MOUTH DISEASE; FOOT AND MOUTH DISEASE VIRUS; GUINEA PIG; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; VIRUS PARTICLE; X RAY ANALYSIS;

BOS TAURUS; CAVIA; CAVIA PORCELLUS; FOOT-AND-MOUTH DISEASE VIRUS; SUS SCROFA;

EID: 0035701974     PISSN: 10451056     EISSN: None     Source Type: Journal    
DOI: 10.1006/biol.2001.0310     Document Type: Conference Paper

References (23)

1. Protection of cattle against FMDV by a synthetic peptide
2. A synthetic vaccine protects humans against challenge with asexual blood stages of Plasmodium falciparum malaria
3. Peptide vaccine against parvovirus: Identification of two neutralization subsites in the N-terminus of VP2 and optimization of the amino acid sequence
4. A large-scale evaluation of peptide vaccines against FMD: Lack of solid protection in cattle and isolation of escape mutants
5. Contact residues and predicted structure of the reovirus type 3-receptor interaction
6. Cross-reactive potential of rabbit antibodies raised against a cyclic peptide representing a chimeric V3 loop of HIV-1 gp120 studied by biosensor technique and ELISA
7. Native-like cyclic peptide models of a viral antigenic site: Finding a balance between rigidity and flexibility
8. Disulfide-bonded discontinuous epitopes on the glycoprotein of vesicular stomatitis virus
9. Synthetic peptides representing discontinuous CD4 binding epitopes of HIV-1 gp120 that induce T cell apoptosis and block cell death induced by gp120
10. Disulfide-bridged heterotrimeric collagen peptides containing the collagenase cleavage site of collagen type I. Synthesis and conformational properties
11. A rationally designed synthetic peptide mimic of a discontinuous antigenic site elicits neutralizing antibodies
12. The three-dimensional structure of FMDV at 2·9 Å resolution
13. Crystallization and preliminary X-ray analysis of three serotypes of FMDV
14. The structure and antigenicity of a type C foot-and-mouth disease virus
15. Mutational analysis of discontinuous epitopes of FMDV using an unprocessed capsid protomer precursor
16. CD of proline-rich polypeptides: Application to the study of the repetitive domain of maize glutelin-2
17. Principles and practice of solid-phase peptide synthesis
18. 3-Nitro-2-pyridinesulfenyl group for protection and activation of the thiol function of cysteine
19. Formation of disulfide bonds in synthetic peptides and proteins
20. Use of the Npys thiol protection in solid phase peptide synthesis. Application to direct peptide-protein conjugation through cysteine residues
21. Protection against FMD by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence
22. Direct evaluation of the immunodominance of a major antigenic site of FMDV in a natural host