MHV neuropathogenesis: The study of chimeric S genes and mutations in the hypervariable region

Advances in Experimental Medicine and Biology

Volumn 494, Issue , 2001, Pages 115-119

  Phillips, Joanna J ^a   Weiss, Susan R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS RNA;

BRAIN; CHIMERA; CONFERENCE PAPER; GENE FUNCTION; GENE MUTATION; GENETIC ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; LD 50; MURINE HEPATITIS CORONAVIRUS; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; RECOMBINANT GENE; VIRAL GENETICS; VIRUS PATHOGENESIS; VIRUS RECOMBINANT; VIRUS REPLICATION; VIRUS VIRULENCE;

CORONAVIRUS; MURINAE; MURINE HEPATITIS VIRUS; RNA VIRUSES;

EID: 0035699345     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-1325-4_18     Document Type: Conference Paper

References (7)

1. Site-specific alteration of murine hepatitis virus type 4 peplomer glycoprotein E2 results in reduced neurovirulence
2. The V5A13.1 envelope glycoprotein deletion mutant of mouse hepatitis virus type-4 is neuroattenuated by its reduced rate of spread in the central nervous system
3. Pathogenicity of antigenic variants of murine coronavirus JHM seleced with monoclonal antibodies
4. Retargeting of coronavirus by substitution of the spike glycoprotein ectodomain: Crossing the host cell species barrier
5. Sequence analysis reveals extensive polymorphism and evidence of deletions within the E2 glycoprotein gene of several strains of murine hepatitis virus
6. Pathogenesis of chimeric MHV4/MHV-A59 recombinant viruses: The murine coronavirus spike protein is a major determinant of neurovirulence
7. The peplomer protcin E2 of coronavirus JHM as a determinant of neurovirulence: Definition of critical epitopes by variant analysis