CJ-13,981 CJ-13,982, new squalene synthase inhibitors

Journal of Antibiotics

Volumn 54, Issue 12, 2001, Pages 1025-1030

  Watanabe, Shuzo ^a   Hirai, Hideo ^a   Kambara, Takahito ^a   Kojima, Yasuhiro ^a   Nishida, Hiroyuki ^a   Sugiura, Ayumu ^a   Yamauchi, Yuji ^a   Yoshikawa, Nobuji ^a   Harwood Jr , H James ^a   Huang, Liang Hsiung ^a   Kojima, Nakao ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY 3,4 DICARBOXY 15 HEXADECANOIC ACID; 3 HYDROXY 3,4 DICARBOXYHEXADECANOIC ACID; BRAIN PROTEIN; CJ 13981; CJ 13982; PROTEIN FARNESYLTRANSFERASE; SQUALENE SYNTHASE; SQUALENE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ISOLATION; DRUG STRUCTURE; ENZYME INHIBITION; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; FERMENTATION; FUNGUS CULTURE; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; LIVER MICROSOME; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

EID: 0035698433     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.54.1025     Document Type: Article

References (15)

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2. Regulation of the mevalonate pathway
3. Zur Kenntniss der Agaricinsäure
4. Absolute configurations of alkylcitric acids
5. Squalestatin 1, a potent inhibitor of squalene synthase, which lowers serum cholesterol in vivo
6. Zaragozic acids: A family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase
7. Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo
8. Posttranslational modification of proteins by isoprenoids in mammalian cells
9. Protein isoprenylation and methylation at carboxyl-terminal cysteine residues
10. Isolation and structure of chaetomellic acids A and B from Chaetomella acutiseta: Farnesyl pyrophosphate mimic inhibitors of Ras farnesyl-protein transferase
11. Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase
12. Measurement of enzymatic activity in 96-well format using TopCount microplate scintillation counting technology
13. HMG-CoA reductase regulation: Use of structurally diverse first half-reaction squalene synthetase inhibitors to characterize the site of mevalonate-derived nonsterol regulator production in cultured IM-9 cells
14. 3-(4-Chlorophenyl)-2-(diethylaminoethoxyphenyl)-A-pentonitrile monohydrogen citrate and related analogs: Reversible, competitive, first half-reaction squalene synthetase inhibitors