Oxidized low density lipoprotein inhibits prostacyclin generation by rat aorta in vitro: A key role of lysolecithin

Prostaglandins and Other Lipid Mediators

Volumn 66, Issue 4, 2001, Pages 283-304

  Mahfouz, Mohamedain M ^a,b   Kummerow, Fred A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b HE Moore Heart Research Foundation   (United States)

Author keywords

Antioxidants; Lysophosphatidylcholine; Oxidized low density lipoprotein; Oxysterols; Prostacyclin; Rat aorta

Indexed keywords

7 OXOCHOLESTEROL; ALKADIENE; ALPHA TOCOPHEROL; ANTIOXIDANT; BUFFER; CATALASE; COPPER; LIPID PEROXIDASE; LOW DENSITY LIPOPROTEIN; LYSOPHOSPHATIDYLCHOLINE; OXYGEN RADICAL; OXYSTEROL; POLYUNSATURATED FATTY ACID; PROSTACYCLIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; HUMAN; LIPID ANALYSIS; LIPID COMPOSITION; MOLECULAR WEIGHT; NONHUMAN; RAT;

ANIMALS; ANTIOXIDANTS; AORTA; CATALASE; EPOPROSTENOL; HUMANS; KETOCHOLESTEROLS; LIPOPROTEINS, LDL; LYSOPHOSPHATIDYLCHOLINES; OXIDATION-REDUCTION; RATS; SOLUTIONS; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; VITAMIN E;

EID: 0035692063     PISSN: 00906980     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-6980(01)00166-6     Document Type: Article

References (70)

1. Low density lipoprotein undergoes oxidative modification in vivo
2. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbits and man
3. Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: Evidence that an antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks slowing the progression of atherosclerosis in the WHHL rabbit
4. The antioxidant butylated hydroxytoluene protects against atherosclerosis
5. Serial coronary angiographic evidence that antioxidant vitamin intake reduces progression of coronary artery atherosclerosis
6. Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells, and smooth muscle cells
7. Mononuclear leukocyte exposed to oxidized low density lipoprotein secrete a factor that stimulates endothelial cells to express adhesion molecules
8. Oxidized low density lipoprotein induces differentiation, and adhesion of human monocytes, and the monocytic cell line U 937
9. Macrophages, endothelial cells, and lipoprotein oxidation in the pathogenesis of atherosclerosis
10. Initiation of atherosclerotic lesions in cholesterol fed rabbits. II: Selective retention of LDL vs. selective increases in LDL permeability in specific sites of arteries
11. Inflammation and infection induce LDL oxidation in vivo
12. 2 production: Correlation with changes in human aortic atherosclerotic disease
13. Decreased prostaglandin production in cultured smooth muscle cells from atherosclerotic rabbit aorta
14. 2 formation in atherosclerotic human carotid artery
15. Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides
16. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibit platelet aggregation
17. Platelet, and blood vessel arachidonate metabolism, and interactions
18. Prostacyclin, and arterial wall biology
19. 2 synthesis by platelets
20. 2
21. Serum lipid profile determines platelet reactivity to native and modified LDL cholesterol in humans
22. Oxidize low density lipoprotein stimulate prostacyclin production by adult human vascular endothelial cells
23. Chronic exposure of cultured bovine endothelial cells to oxidized LDL abolishes prostacyclin release
24. Probucol inhibits oxidized low density lipoprotein induced adhesion of monocytes to endothelial cells by reducing P selectin synthesis in vitro
25. Lipid hydroperoxy and hydroxy derivatives in copper catalyzed oxidation of low density lipoprotein
26. Autoxidation of human low denisity lipoprotein: Loss of polyunsaturated fatty acids, and vitamin E, and generation of aldehydes
27. Varying susceptibility of different low density lipoprotein to oxidative modification
28. Focal toxicity of oxysterols in vascular smooth muscle cell culture: A model of the atherosclerotic core region
29. Lysophosphatidylcholine: A chemotactic factor for human monocytes, and its potential role in atherogenesis
30. Fractionation of plasma lipoproteins
31. A simplification of the protein assay method of Lowry, et al. which is more generally applicable
32. Oxy-mediated heterogeneity of apo low density lipoprotein
33. ++ in the presence of xylenol orange. Comparison with the TBA assay and iodometric method
34. Cholesterol oxides in plasma, and lipoproteins of magnesium deficient rabbits, and effects of their lipoproteins on endothelial barrier function
35. A simple method for the isolation, and purification of total lipids from animal tissues
36. The maturation of rat brain myelin
37. Interrelationship between dietary trans fatty acids, and the 6-, and 9- desaturases in the rat
38. Changes of linoleic acid metabolism, and cellular phospholipid fatty acid composition in LLC-PK cells cultured at low magnesium concentration
39. Inactivation of endothelial derived relaxing factor by oxidized lipoproteins
40. A rapid method of total lipid extraction, and purification
41. Modulation of platelet thromboxane, and arterial prostacyclin by dietary vitamin E
42. Assay of prostacyclin synthesis in intact aorta by aqueous sampling
43. Endocytosis
44. Binding, and degradation of low density lipoprotein by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous hypercholesterolemia
45. Injury to human endothelial cells in culture by low density lipoproteins
46. The low density lipoprotein pathway, and its relation to atherosclerosis
47. Injury to human cell in culture induced by low density lipoprotein: An effect independent of receptor binding, and endocytotic uptake of low density lipoprotein
48. Inhibition of inducible nitric oxide synthase in macrophages by oxidized low density lipoprotein
49. Role of oxidatively modified LDL in atherosclerosis
50. Influence of cholesterol oxides, and antioxidants on prostacyclin production by cultured endothelial cells
51. Effect of cholestanetriol on cytotoxicity, and prostacyclin production in cultured rabbit aortic endothelial cells
52. Effect of 25-hydroxycholesterol on cytotoxicity, and prostacyclin production in cultured human umbilical arterial endothelial cells
53. 25-Hydroxycholesterol increases eicosanoids, and alters morphology in cultured pulmonary artery smooth muscle, and endothelial cells
54. Membrane lipid composition, and cellular function
55. Membrane function, and vascular reactivity
56. Specific, and nonspecific stimulation of prostaglandin release by human skin fibroblasts in culture: Are changes of membrane fluidity involved?
57. Parameters affecting the liposome mediated insertion of RNA into eukaryotic cells in vitro
58. Lysophosphatidylcholine concentrations, and metabolism in aortic intima plus inner media: Effect of nutritionally induced atherosclerosis
59. Inhibition of prostaglandin synthesis by lysolecithin
60. Transport of biological lipophiles: Effect of lipophile structure
61. Modification of human serum low density lipoprotein by oxidation-characterization, and pathophysiological implications
62. Lipid peroxide inhibits the enzyme in blood vessel microsomes that generate from prostaglandin endoperoxide the substance which prevent platelet aggregation
63. Further studies on the enzymatic conversion of prostaglandin peroxide into prostacyclin by porcine aorta microsomes
64. Dietary supplementation with vitamin E in hyperlipoproteinemia: Effect on plasma lipid peroxides, antioxidant activity, prostacyclin generation, and platelet aggregability
65. Serum lipoproteins, lipid peroxides and prostacyclin biosynthesis in patients with coronary heart disease
66. Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human, and rabbit arterial endothelial cells
67. Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid
68. Antioxidants, lipoprotein oxidation, and arterial function
69. Role of oxidized low density lipoprotein in atherogenesis