Inhalation of α1-protease inhibitor in cystic fibrosis does not affect surfactant convertase and surface activity

Pulmonary Pharmacology and Therapeutics

Volumn 14, Issue 6, 2001, Pages 461-467

  Griese, M ^a   Von Bredow, C ^a   Birrer, P ^a   Schams, A ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Carboxyl esterase; Convertase; Surface tension; Surfactant; 1 antitrypsin; 1 protease inhibitor

Indexed keywords

ALPHA 1 ANTITRYPSIN; CARBOXYLESTERASE; LUNG SURFACTANT; PROTEIN BAL; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; ASSAY; CELL AGGREGATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; DISEASE ASSOCIATION; FEMALE; HUMAN; LUNG ALVEOLUS SURFACE TENSION; LUNG INJURY; LUNG LAVAGE; MALE; METABOLISM; PRIORITY JOURNAL; PROTEIN DEGRADATION; TREATMENT PLANNING; ULTRACENTRIFUGATION;

EID: 0035686310     PISSN: 10945539     EISSN: None     Source Type: Journal    
DOI: 10.1006/pupt.2001.0317     Document Type: Article

References (27)

1. Cystic fibrosis
2. Protease-antiprotease imbalance in the lungs of children with cystic fibrosis
3. Biochemical and pathological evidence for proteolytic destruction of lung connective tissue in cystic fibrosis
4. Proteolytic cleavage of ICAM-1 by human neutrophil elastase
5. The role of neutrophil elastase in chronic inflammation
6. Complement receptor expression on neutrophils at an inflammatory site, the pseudomonas-infected lung in cystic fibrosis
7. Proteins of the cystic fibrosis respiratory tract
8. Neutrophil elastase cleaves C3bi on opsonised Pseudomonas as well as CR1 on neutrophils to create a functionally important opsonin receptor mismatch
9. Cleavage of lymphocyte surface antigens CD2, CD4 and CD8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis
10. Pulmonary surfactant in cystic fibrosis
11. Deficient hydrophilic lung surfactant proteins A and D with normal surfactant phospholipid molecular species in cystic fibrosis
12. Extracellular metabolism of pulmonary surfactant: The role of a new serine protease
13. Serine protease requirement for the extracellular metabolism of pulmonary surfactant
14. The role of α1-antitrypsin in the control of extracellular surfactant metabolism
15. Addition of 1-antitrypsin to surfactant improves oxygenation in surfactant-deficient rats
16. Lung 'surfactant convertase' is a member of the carboxylesterase family
17. Molecular cloning, characterization, and differential expression pattern of mouse lung surfactant convertase
18. Identification of a putative surfactant convertase in rat lung as a secreted serine carboxylesterase
19. Stabilisation of lung surfactant particles against conversion by a cycling interface
20. Reduced proteolysis of surfactant protein A and changes of the bronchoalveolar lavage fluid proteome by inhaled α1-protease inhibitor in cystic fibrosis
21. Localisation of a candidate surfactant convertase to type II cells, macrophages, and surfactant subfractions
22. An examination of the different variables affecting surfactant aggregate conversion in vitro
23. Surfactant subtype conversion is related to loss of surfactant apoprotein B and surface activity in large surfactant aggregates
24. Effects of lung injury on pulmonary surfactant aggregate conversion in vivo and in vitro
25. Degradation of surfactant-associated protein B (SP-B) during in vitro conversion of large to small surfactant aggregates
26. Protein-lipid interactions and enzyme requirements for light subtype generation on cycling reconstituted surfactant