Nifedipine limits infarct size via NO-dependent mechanisms in dogs

Basic Research in Cardiology

Volumn 96, Issue 5, 2001, Pages 497-505

  Asanuma, Hiroshi ^a   Kitakaze, Masafumi ^a   Funaya, Hiroharu ^a   Takashima, Seiji ^a   Minamino, Tetsuo ^a   Node, Koichi ^a   Sakata, Yasuhiko ^a   Asakura, Masanori ^a   Sanada, Shoji ^a   Shinozaki, Yoshiro ^b   Mori, Hidezo ^b   Kuzuya, Tsunehiko ^a   Tada, Michihiko ^a   Hori, Masatsugu ^a  

^a OSAKA UNIVERSITY   (Japan)

^b TOKAI UNIVERSITY   (Japan)

Author keywords

Ca channel; Endothelium; Ischemia; NO; Reperfusion

Indexed keywords

AMLODIPINE; BRADYKININ; CALCIUM CHANNEL BLOCKING AGENT; MYELOPEROXIDASE; N(G) NITROARGININE METHYL ESTER; NIFEDIPINE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY BLOOD VESSEL; DISEASE MODEL; DOG; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; DRUG INFUSION; DRUG MECHANISM; ENZYME ACTIVITY; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; HEART RATE; HEMODYNAMIC PARAMETERS; IN VITRO STUDY; NONHUMAN; REPERFUSION INJURY;

ANIMALS; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CORONARY CIRCULATION; DOGS; ENDOTHELIUM; ENZYME INHIBITORS; HEART RATE; MYOCARDIAL INFARCTION; NG-NITROARGININE METHYL ESTER; NIFEDIPINE; NITRIC OXIDE; PEROXIDASE;

EID: 0035686304     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003950170032     Document Type: Article

References (47)

1. Expression of nitric oxide synthase in human peripheral blood mononuclear cells and neutrophils
2. Limitation of reperfusion injury by a monoclonal antibody to C5a during myocardial infarction in pigs
3. Cytokine-mediated apoptosis in cardiac myocytes: The role of inducible nitric oxide synthase induction and peroxynitrite generation
4. Endothelial and neuro-humoral control of coronary blood flow in health and disease
5. Current status of platelet NO synthases
6. Evidence that late preconditioning against myocardial stunning in conscious rabbits is triggered by the generation of nitric oxide
7. Evidence for the presence of L-arginine-nitric oxide pathway in human red blood cells: Relevance in the effects of red blood cells on platelet function
8. Renoprotective effects of nitric oxide in angiotensin II-induced hypertension in the rat
9. Endothelium inhibits norepinephrine release from adrenergic nerves of rabbit carotid artery
10. Benidipine improves endothelial function in renal resistance arteries of hypertensive rats
11. Salicylate or aspirin inhibits the induction of the inducible nitric oxide synthase in rat cardiac fibroblasts
12. 2 consumption in the nonhuman primate: An additional mechanism of action of amlodipine
13. Efficacy of benidipine hydrochloride on myocardial ischemia and reperfusion
14. Effects of vasodilators and perfusion pressure on coronary flow and simultaneous release of nitric oxide from guinea pig isolated hearts
15. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
16. 15N]nitrate in biological fluid
17. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
18. NG-monomethyl L-arginine inhibits endothelium-derived relaxing factor-stimulated cyclic GMP accumulation in cocultures of endothelial and vascular smooth muscle cells by an action specific to the endothelial cell
19. Protection of endothelial damage and systemic shock by benidipine, a calcium antagonist, in rats subjected to splanchnic ischemia and reperfusion
20. Effect of nifedipine on cyclic GMP turnover in cultured coronary smooth muscle cells
21. 1-Adrenoceptor activity regulates release of adenosine from the ischemic myocardium in dogs
22. 1-adrenoceptor activation mediates the infarct size limiting effect of ischemic preconditioning through augmentation of 5′-nucleotidase activity and adenosine release
23. Evidence for nitric oxide generation in the cardiomyocytes. Its augmentation by hypoxia
24. Nifedipine-induced coronary vasodilation in ischemic hearts is attributable to bradykinin- and NO-dependent mechanisms in dogs
25. Endothelium-dependent actions of dihydropyridine calcium antagonist: Vascular endothelium, physiology, pathology and therapeutic opportunities
26. Marked nitration by stimulation with lipopolysaccaride in ascorbic acid-deficient rats
27. Long-term use of angiotensin-converting enzyme inhibitors to modify endothelial dysfunction: A review of clinical investigations
28. w-nitro-L-arginine methyl ester in the cat
29. Nitric oxide from vascular smooth muscle cells: Regulation of platelet reactivity and smooth muscle cell guanylate cyclase
30. Nitric oxide in the vasculature: Physiology and pathophysiology
31. New nonradioactive microspheres and more sensitive X-ray fluorescence to measure regional blood flow
32. Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning
33. Endogenous nitric oxide reduces myocardial inotropic responses in ischemic myocardium of the canine heart
34. Decreased plasma levels of nitric oxide in patients with essential hypertension
35. Should calcium antagonist be used after myocardial infarction? Ischemia selectivity versus vascular selectivity
36. Nitric oxide from L-arginine
37. Hypoxia stimulates release of endothelium-derived relaxant factor
38. Nitric oxide triggers late preconditioning against myocardial infarction in conscious rabbits
39. 2+ antagonist-induced vasodilation. Intracellular actions
40. Endothelium-derived relaxing factor reduces platelet adhesion to bovine endothelial cells
41. Induction of apoptosis in myocardial infarction and its possible relationship to nitric oxide synthase in macrophages
42. Generation of nitric oxide by human neutrophils
43. Role of endothelium-derived nitric oxide in myocardial reactive hyperemia
44. Effects of benidipine, a calcium antagonist, on urinary kallikrein excretion and renal impairment in experimental diabetes
45. Amlodipine releases nitric oxide from canine coronary microvessels: An unexpected mechanism of action of a calcium channel-blocking agent