Molecular analysis of cross-reactive human monoclonal antibody AE6F4 generated by in vitro immunization: Epitope mapping of AE6F4 antibody on 14-3-3 family proteins and cytokeratin 8

Cytotechnology

Volumn 36, Issue 1-3, 2001, Pages 101-107

  Ichikawa, Akira ^a   Shim, Sun Yup ^b   Katakura, Yoshinori ^b   Teruya, Kiichiro ^b   Hashizume, Shuichi ^c   Shirahata, Sanetaka ^b  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c 2 1 1 Shimosueyoshi   (Japan)

Author keywords

14 3 3 proteins; Cytokeratin 8; Epitope mapping; Human monoclonal antibody; Overlapping synthetic peptides

Indexed keywords

EID: 0035686102     PISSN: 09209069     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1014060113186     Document Type: Conference Paper

References (10)

1. Cytokeratin 8 and 19 as antigens recognized by adenocarcinoma-reactive human monoclonal antibody AE6F4
2. In vitro immunization of human peripheral blood lymphocytes with human cancer cell line A549
3. Molecular cloning of the 31 kDa cytosolic phospholipase A2, as an antigen recognized by the lung cancer specific human monoclonal antibody, AE6F4
4. Elevated expression levels of the 14-13-3 family of proteins in lung cancer tissues
5. Specific reactivity of human monoclonal antibody AE6F4 against cancer cells in tissues and sputa from lung cancer patients
6. The 14-13-3 protein as the antigen for lung cancer-associated human monoclonal antibody AE6F4
7. Cytokeratin 19 fragments: A new marker for non-small-cell lung cancer
8. Identification of genes overexpressed in head and neck squamous cell carcinoma using a combination of complementary DNA subtraction and microarray analysis
9. Detection of monoclonal antibodies specific for carbohydrate epitopes using periodate oxidation
10. Increased expression of cytokeratins CK8 and CK19 is associated with head and neck carcinogenesis