Phage-display evolution of tyrosine kinases with altered nucleotide specificity

Biopolymers - Peptide Science Section

Volumn 60, Issue 3, 2001, Pages 220-228

  Ting, Alice Y ^a   Witte, Krista ^a   Shah, Kavita ^b   Kraybill, Brian ^c   Shokat, Kevan M ^c   Schultz, Peter G ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ATP anatog; Functional selection; In vitro evolution; Nucleotide specificity; Orthogonal kinase; Phage display; Phosphorylation; ; Src; Tyrosine kinase

Indexed keywords

CLONING; GENES; MAPPING; PROTEINS;

PHOSPHORYLATE SUBSTRATES;

BIOPOLYMERS;

6 N BENZYLADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; MUTANT PROTEIN; NUCLEOTIDE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; ENZYME ACTIVITY; ENZYME SPECIFICITY; GENOME; PHAGE DISPLAY; PROTEIN PHOSPHORYLATION; PROTEOMICS;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; ARGININE; BASE SEQUENCE; BLOTTING, WESTERN; CATALYSIS; DNA; ESCHERICHIA COLI; KINETICS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDE LIBRARY; PHOSPHORYLATION; PROTEIN ENGINEERING; PROTEIN-TYROSINE KINASES; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035682509     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0282(2001)60:3<220::AID-BIP10035>3.0.CO;2-C     Document Type: Article

References (19)